small win: SURMOUNT stopped being a problem at week 65
Right, the SURMOUNT question again, but with numbers this time.
I have 5 data points over 6 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.
The thing I would flag for anyone new: the effect I am describing showed up at week 60, not week 14. People give up long before the interesting part.
Interested in whether this matches other people's logs or whether I am an outlier.
best — the order this archive was captured in
Disagree. What you are describing is consistent with endpoint, not with what you concluded.
Removed a chain here. The rule is one line long and it is not negotiable.
Yeah, absolute numbers matter more than the press release.
Not convinced. The evidence does not support that reading.
phase 2 is not phase 3, smaller n and shorter trial
press release TRIUMPH posts must be flaired until a publication exists
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
I am going to push back on this slightly.
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
the discontinuation arms are the interesting part, not the STEP endpoints
give the trial name, phase, n, and primary endpoint in the body
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
Yeah, absolute numbers matter more than the press release.
dropout handling matters, especially on GI-heavy populations
Strongly agree. Phase 2 is investigational, not conclusive.
give the trial name, phase, n, and primary endpoint in the body
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
Yes, exactly this, and it is the bit that took me 47 weeks to accept.
the 18 week readout is different from the 6 week readout
phase 2 is not phase 3, smaller n and shorter trial
phase 2 is not phase 3, smaller n and shorter trial
Disagree on that part. 99.0% and 98.9% on the same vial is normal.
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
I am going to push back on this slightly.
You have restated the marketing copy. What is the actual substance here.
off-label use data is different from approved-indication data
press release SURPASS posts must be flaired until a publication exists
press release hazard ratio posts must be flaired until a publication exists
I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.
Strongly agree. Phase 2 is investigational, not conclusive.
- 1STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix11 comments in this branch · started by u/rina_sobczak
- 2the 18 week readout is different from the 6 week readout9 comments in this branch · started by u/formulary_fighter