GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Archived. This submission is more than a year old. Votes and new comments are closed, and some of the advice in it may have been superseded — check the community wiki for the current version.
7.4k
c/trialwatch·posted 2 years ago by u/alcohol_aversion

[PSA] SURMOUNT is not what most of this community thinks it is

Trial Data Clean Column ×5 Slow Clap ×1 Long Haul ×3

Right, the TRIUMPH question again, but with numbers this time.

I have 5 data points over 38 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 80, not week 34. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

8,245 up / 864 down91% upvoted35 commentsid 62b82l31 May 2024

35 comments

17 in this archive, depth 5

best — the order this archive was captured in

u/hazard_ratio_halstats394 points·2 years ago
this is the third time this week and i love it every time
replysharereportpermalink
u/milos_trevino384 points·2 years ago

This is correct. Discontinuation arms show the regain reality.

replysharereportpermalink
u/nayeli_fonseca312 points·2 years ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

replysharereportpermalink
u/ms_fragmenter244 points·2 years ago

Sceptical. If this were true we would see it reflected in the data and we do not.

replysharereportpermalink
u/nikhil_lindqvist56 points·2 years ago

the 5 week readout is different from the 32 week readout

replysharereportpermalink
u/nordic_pricing259 points·2 years ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

replysharereportpermalink
u/formulary_fighterappeals0 points·2 years ago

This is correct. Discontinuation arms show the regain reality.

replysharereportpermalink
u/tomas_kimani1 point·2 years ago·edited

Respectfully this is a sample of one presented as a finding.

replysharereportpermalink
u/laila_almeida1 point·2 years ago

event rates are more informative than hazard ratios alone

replysharereportpermalink
u/alcohol_aversionOP1 point·2 years ago

the relative risk reduction in headlines is not the whole story

replysharereportpermalink
u/renal_outcomes_rMOD147 points·2 years ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

replysharereportpermalink
u/aurel_mwangi-15 points·2 years ago

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

replysharereportpermalink
u/yusuf_achebe108 points·2 years ago

dropout handling matters, especially on GI-heavy populations

replysharereportpermalink
u/tove_ogunleye199 points·2 years ago

That is net peptide content, not purity. Different number, different meaning.

replysharereportpermalink
u/receptor_bias_rick163 points·2 years ago

event rates are more informative than hazard ratios alone

replysharereportpermalink
u/cloudy_vial_carol91 points·2 years ago

Strongly agree. Phase 2 is investigational, not conclusive.

replysharereportpermalink
u/rina_bergstrom79 points·2 years ago

the discontinuation arms are the interesting part, not the endpoint endpoints

replysharereportpermalink
Permalinked branches
Deep branches get their own page so a single reply chain can be linked and read on its own.
About c/trialwatch

Clinical trial reading group. New readouts, protocol amendments, endpoint definitions, dropout handling, and the difference between a press release and a publication. Absolute risk reduction and number-needed-to-treat are house dialect here.

34kmembers
95submissions
Nov 2023created
submissions / month, last year
Sponsored

PeptideMeter Analytics

Independent testing plus vendor-level trend data. Community-funded, unaffiliated.

peptidemeter.com
More in c/trialwatch
c/trialwatch rules
  1. Press-release-only posts must be flaired Press Release until a publication exists.
  2. Give the trial name, phase, n, and primary endpoint in the body.
  3. Relative risk reduction alone is not a result. Show the absolute numbers.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Full rules and how they are enforced →
Moderators
u/trialwatch_theou/forest_plot_fionau/hazard_ratio_halu/renal_outcomes_r
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.

Full disclaimer →