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c/trialwatch·posted 2 years ago by u/formulary_fighter

does SURPASS actually matter or is it forum lore at this point

Press Release Well Actually ×2 Slow Clap ×3 Cold Box ×1

Posting this because I searched for it and got nothing useful.

Setup: 2.5mg, week 5, constipation present but not ruining anything. I changed exactly one variable — TRIUMPH — and tracked it for 9 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

8,021 up / 3,049 down72% upvoted49 commentsid 4od7lq6 Apr 2024

49 comments

10 in this archive, depth 5

best — the order this archive was captured in

u/sten_palacios476 points·2 years ago

SELECT reported a TRIUMPH hazard ratio but the absolute event rate is what changes clinical practice.

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u/alcohol_aversion130 points·2 years ago

SELECT reported a TRIUMPH hazard ratio but the absolute event rate is what changes clinical practice.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/annika_fonseca63 points·2 years ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/nayeli_fonseca50 points·2 years ago·edited

the relative risk reduction in headlines is not the whole story

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u/rohan_cardoso16 points·2 years ago

I am going to push back on this slightly.

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u/naomi_ekstrom63 points·2 years ago

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

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u/curious_panel_only153 points·2 years ago

Strongly agree. Phase 2 is investigational, not conclusive.

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u/karl_fischer_kev463 points·2 years ago

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

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u/formulary_fighterOPappeals185 points·2 years ago

SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.

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u/forest_plot_fionaMOD237 points·2 years ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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