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c/trialwatch·submitted 2 years ago by u/alcohol_aversion

[PSA] SURMOUNT is not what most of this community thinks it is

Trial Databranch of 9 comments

Right, the TRIUMPH question again, but with numbers this time. I have 5 data points over 38 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am describing…

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9 comments, started 2 years ago
u/nordic_pricing259 points·2 years ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/formulary_fighterappeals0 points·2 years ago

This is correct. Discontinuation arms show the regain reality.

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u/tomas_kimani1 point·2 years ago·edited

Respectfully this is a sample of one presented as a finding.

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u/laila_almeida1 point·2 years ago

event rates are more informative than hazard ratios alone

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u/alcohol_aversionOP1 point·2 years ago

the relative risk reduction in headlines is not the whole story

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u/renal_outcomes_rMOD147 points·2 years ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/aurel_mwangi-15 points·2 years ago

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

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u/yusuf_achebe108 points·2 years ago

dropout handling matters, especially on GI-heavy populations

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u/tove_ogunleye199 points·2 years ago

That is net peptide content, not purity. Different number, different meaning.

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