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c/trialwatch·submitted 1 year ago by u/anders_vermeulen

does FLOW actually matter or is it forum lore at this point

Readoutbranch of 13 comments

Trying to settle this properly because the thread from last year went in circles. The claim: FLOW matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 22 months without either producing anything. What would actually settle it is 3 people measuring the same thing…

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13 comments, started 1 year ago
u/sofia_ferreira13 points·1 year ago·edited
genuine question, not being difficult: how do you know
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u/foam_head_fred-27 points·1 year ago

genuine question, not being difficult: how do you know

Disagree on that part. 98.1% and 98.9% on the same vial is normal.

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u/niels_norgaard1 point·1 year ago

Strongly agree. Phase 2 is investigational, not conclusive.

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u/joaquin_trevino1 point·1 year ago

the 11 week readout is different from the 5 week readout

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u/rina_sobczak1 point·1 year ago

give the trial name, phase, n, and primary endpoint in the body

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u/anders_vermeulenOP1 point·1 year ago

genuine question, not being difficult: how do you know Disagree on that part.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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[removed]1 point·1 year ago

[removed by moderator]

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u/joaquin_trevino1 point·1 year ago

event rates are more informative than hazard ratios alone

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u/milan_mensah1 point·1 year ago

the 18 week readout is different from the 19 week readout

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u/foam_head_fred1 point·1 year ago

I am going to push back on this slightly.

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u/customs_seizure_sid7 points·1 year ago

Not convinced. The evidence does not support that reading.

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u/yusuf_ramos4 points·1 year ago

the relative risk reduction in headlines is not the whole story

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u/laila_almeida2 points·1 year ago

dropout handling matters, especially on GI-heavy populations

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