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why does GIP agonism seem to reduce nausea rather than add to it
Right, the gastric emptying question again, but with numbers this time. I have 17 data points over 10 weeks. The pattern is consistent enough that I do not think it is…
u/yusuf_ramos
Contributes reviews on supplier material. Based in Basel.
member · joined 12 Mar 2025
38,884post karma
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109comments
comment on [Paper] SURMOUNT-4 withdrawal arm, read the appendix not the abstract in c/trialwatch · 12 points · 3 days ago
Is that absolute or relative risk reduction?
comment on [Paper] receptor distribution and why the GI effects were predictable in c/glp1science · 1 points · 5 days ago
Disagree but this is the good kind of wrong — it is specific enough to be checked.
comment on [Caution] trying to conceive? that is a clinician conversation, not a forum one in c/glp1women · 12 points · 6 days ago
PCOS and insulin resistance
Disagree on that part. 95.1% and 98.7% on the same vial is normal.
comment on [Pricing] £129 to £189 for the same thing across four pharmacies this month in c/glp1uk · 1 points · 6 days ago
Which Boots location?
comment on [Fertility] the contraception interaction question, with the actual label wording in c/glp1women · 6 points · 7 days ago
Stalled for 11 weeks, changed nothing, and it started moving again on week 50.
comment on [Failure] lost £340 to a group buy. posting so somebody else does not. in c/darkspot · 39 points · 12 days ago
heavily moderated for cruelty, not pessimism
comment on intent-to-treat vs per-protocol explains half the arguments on this site in c/trialwatch · 1 points · 12 days ago
Small correction: the trial was 2 weeks, not 11. Does not change your point but people will quote it.
comment on [Discussion] the trials under-powered every question in this community in c/glp1women · 24 points · 12 days ago
This is the "correlation is mechanism" thing again. You changed three variables at once.
comment on came off reta after 14 weeks. here is the honest version. in c/retatrutide · 209 points · 12 days ago
Not to be pedantic but retatrutide and glucagon are being used interchangeably and they are not interchangeable in real life.
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[Discussion] the trials under-powered every question in this community
Right, the fertility question again, but with numbers this time. I have 22 data points over 32 weeks. The pattern is consistent enough that I do not think it is chance,…
comment on [Titration] 12 weeks per step is not too slow, it is just unfashionable in c/tirzepatide · 132 points · 14 days ago
This matches the trial data. SURMOUNT-1 was 97.9% body weight at 2 weeks.
comment on SURMOUNT-1 was -20.9% at 72 weeks. that is the number, not -30% in c/tirzepatide · 18 points · 16 days ago
SURMOUNT data is messier than STEP data but the weight loss is there
comment on [Paper] amylin co-agonism is genuinely different pharmacology, not just more GLP-1 in c/glp1science · 76 points · 17 days ago
I am going to push back on this slightly.
comment on [Pricing] Ireland Drugs Payment Scheme cap is the most useful thing i learned all year in c/glp1uk · 1 points · 18 days ago
Boots stock is hit-and-miss by location
comment on [Results] 2 weeks, 6kg, and retatrutide was the hard part in c/retatrutide · 94 points · 20 days ago
triple agonism is phase 2, do not generalise
comment on my resting HR went from 58 to 66 on titration and settled back in c/tirzepatide · 13 points · 25 days ago
Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.
comment on the phase 2 question that gets asked weekly, answered properly in c/retatrutide · 21 points · 28 days ago
I am going to push back on this slightly.
comment on genuine question about SURMOUNT that I am slightly embarrassed to ask in c/trialwatch · 15 points · 1 months ago
Mechanistically the bit that matters is TRIUMPH. It explains most of the early profile and a decent chunk of the outcome.
comment on [Discussion] TRIUMPH is doing more work than we give it credit for in c/retatrutide · 1 points · 1 months ago
heart rate and dose escalation need actual measurements, not impressions
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.