[Results] 47 weeks, 36kg, and SURPASS was the hard part
Trying to settle this properly because the thread from last year went in circles. The claim: STEP matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 20 months without either producing anything. What would actually settle it is 13 people measuring the same…
the 6 week readout is different from the 7 week readout
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
off-label use data is different from approved-indication data
press release hazard ratio posts must be flaired until a publication exists
the discontinuation arms are the interesting part, not the SURMOUNT endpoints
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
off-label use data is different from approved-indication data
off-label use data is different from approved-indication data
Yes, exactly this, and it is the bit that took me 72 weeks to accept.
Strongly agree. Phase 2 is investigational, not conclusive.
dropout handling matters, especially on GI-heavy populations
This is correct. Discontinuation arms show the regain reality.
give the trial name, phase, n, and primary endpoint in the body
Small correction: the trial was 2 weeks, not 16. Does not change your point but people will quote it.
Yeah, absolute numbers matter more than the press release.
the relative risk reduction in headlines is not the whole story