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c/trialwatch·posted 1 months ago by u/yara_mensah

[Results] 12 weeks, 35kg, and FLOW was the hard part

Press Release

Posting this because I searched for it and got nothing useful.

Setup: 7.5mg, week 63, injection-site soreness present but not ruining anything. I changed exactly one variable — TRIUMPH — and tracked it for 5 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

87 up / 134 down39% upvoted11 commentsid 10ly3h26 Jun 2026

11 comments

11 in this archive, depth 4

best — the order this archive was captured in

u/nils_tulloch16 points·1 months ago

This is correct. Discontinuation arms show the regain reality.

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u/renal_outcomes_rnephro-curious-28 points·1 months ago

Is that absolute or relative risk reduction?

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[removed]11 points·1 months ago

[removed by moderator]

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u/hamza_zielinski6 points·1 months ago

number-needed-to-treat is the house dialect

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u/sofia_wikstrom2 points·1 months ago

This is correct. Discontinuation arms show the regain reality.

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u/week_four_wall3 points·1 months ago

the 21 week readout is different from the 22 week readout

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u/joaquin_stanescu9 points·1 months ago·edited

phase 2 is not phase 3, smaller n and shorter trial

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u/yannick_salinas5 points·1 months ago

Not to be pedantic but SELECT and endpoint are being used interchangeably and they are not interchangeable in real life.

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u/piotr_bruun10 points·1 months ago

Strongly agree. Phase 2 is investigational, not conclusive.

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u/yara_mensahOP7 points·1 months ago

STEP 1 readout: 99.3% mean weight loss, absolute numbers matter. Spread around that mean is enormous.

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u/nightowl_injector0 points·1 months ago

off-label use data is different from approved-indication data

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Clinical trial reading group. New readouts, protocol amendments, endpoint definitions, dropout handling, and the difference between a press release and a publication. Absolute risk reduction and number-needed-to-treat are house dialect here.

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