Evening dosing sleeps through the worst of it. Anecdote, not advice.
member · joined 13 Mar 2025
comment on nausea day 2 post-injection like clockwork, week 14, does it ever stop in c/sideeffects · 104 points · 1 days ago
and this is why moving to friday evening works. it does not reduce anything, it just moves day 2 onto a saturday.
comment on FLOW got published and nobody in here is talking about eGFR slope in c/trialwatch · 15 points · 2 days ago
Mechanistically the bit that matters is SELECT. It explains most of the early profile and a decent chunk of the outcome.
comment on [Explainer] half-life is 168 hours. that is why your injection day barely matters. in c/glp1science · 132 points · 2 days ago
this explains why moving to friday evenings worked for me. it did not change the drug, it moved the worst two days onto a weekend.
comment on [Log] week 78, dose, weight, waist, sides, labs. nothing hidden. in c/dosinglogs · 1 points · 2 days ago
This is the "correlation is mechanism" thing again. You changed three variables at once.
comment on [Log] week 78, dose, weight, waist, sides, labs. nothing hidden. in c/dosinglogs · 5 points · 2 days ago
Week 74 for me and the honest summary is: 42kg down, injection-site soreness manageable, and I have thought about food maybe four times today.
comment on [Log] week 78, dose, weight, waist, sides, labs. nothing hidden. in c/dosinglogs · 4 points · 3 days ago
the 15 month update is the real test
comment on [Failure] gel pack arrived liquid and warm. photos at unboxing. in c/coldchain · 3 points · 3 days ago
time-at-temperature integral is the dose, not just peak temperature
comment on [Data] logger trace: 6 days transit, 41 hours above 8°C, powder was fine in c/coldchain · 26 points · 3 days ago
Reconstituted or dry powder?
comment on [Log] eight weeks in, here’s the actual schedule and what each step felt like in c/tirzepatide · 68 points · 3 days ago
same logic for me, evening also means I sleep through the worst of the first-day fatigue
comment on [Log] eight weeks in, here’s the actual schedule and what each step felt like in c/tirzepatide · 29 points · 3 days ago
that's genuinely why I posted it, glad it's doing that job
comment on [Log] eight weeks in, here’s the actual schedule and what each step felt like in c/tirzepatide · 12 points · 3 days ago
noted, starting a proper spreadsheet from week 9 onward, this comment section talked me into it
comment on two weeks in, scale hasn’t moved, is that actually normal in c/semaglutide · 34 points · 3 days ago
same boat at week 2 last year. by week 6 it was undeniable. patience is the actual medicine here.
Posting the boring version of a titration log because I wish I'd had one with this much unremarkable detail before I started. Weeks 1–4: starter dose, mild fatigue day…
Trying to settle this properly because the thread from last year went in circles. The claim: dose history matters. The counter-claim: it is measurement error. Both…
comment on [Update] week 44 — first stall in eleven months in c/dosinglogs · 10 points · 4 days ago
Australia here. Waited 24 months on a list, gave up, went private, and the total cost was roughly what I expected.
comment on [Paper] SURMOUNT-4 withdrawal arm, read the appendix not the abstract in c/trialwatch · 22 points · 5 days ago
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
comment on week two, nothing is happening, everyone says that is normal, is it in c/newbiequestions · 1 points · 5 days ago
what is a COA — certificate of analysis, document from the lab
comment on week two, nothing is happening, everyone says that is normal, is it in c/newbiequestions · -6 points · 5 days ago
what is a COA — certificate of analysis, document from the lab
comment on [Explainer] lyophilised powder is far more forgiving than you think in c/coldchain · 94 points · 6 days ago
Yeah, data logger is the only acceptable proof.
comment on [Data] my fridge is 2.1°C at the back and 7.8°C in the door. same fridge. in c/coldchain · 12 points · 11 days ago
time-at-temperature integral is the dose, not just peak temperature
Independent HPLC and mass spec. The number you get is the number they found.
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