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c/t2dglp1·posted 1 year ago by u/thandi_solberg

metformin: the version I wish someone had shown me in week 1

CGM Cold Box ×5 Long Haul ×1

Right, the A1c question again, but with numbers this time.

I have 20 data points over 16 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 51, not week 5. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

1,487 up / 201 down88% upvoted42 commentsid wxqakh10 Dec 2024

42 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/fasting_insulin_fMOD261 points·1 year ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/lucia_balogun113 points·1 year ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/nhs_waitlist_nUK0 points·1 year ago

CGM traces tell a story, numbers alone do not

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u/osman_ferrari182 points·1 year ago·edited

What was the batch number and which service?

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u/thandi_solbergOP-33 points·1 year ago

Ireland here. Waited 16 months on a list, gave up, went private, and the total cost was roughly what I expected.

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u/thandi_solbergOP119 points·1 year ago

What are you comparing it against though?

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u/sock_puppet_spotter51 points·1 year ago

insulin and sulfonylurea interactions are real hypo risk

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u/thandi_solbergOP0 points·1 year ago

CGM traces tell a story, numbers alone do not

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u/santiago_rasmussen40 points·1 year ago

metformin combo is standard

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u/bastian_eriksen47 points·1 year ago

CGM traces tell a story, numbers alone do not

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u/marta_weiss92 points·1 year ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/emil_okwuosa72 points·1 year ago

glycaemic control first, that is the original indication

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u/marta_weiss43 points·1 year ago

type 2 is the indication, weight loss is the side effect

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u/stubborn_batchlist_maybe33 points·1 year ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/farid_jansen35 points·1 year ago

type 2 is the indication, weight loss is the side effect

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/santiago_rasmussen19 points·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/arne_nyberg83 points·1 year ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/adnan_karlsen52 points·1 year ago

The reflux was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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u/lucia_balogun55 points·1 year ago·edited

Which country? Half the answers in this thread only apply in France.

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[removed]41 points·1 year ago

[removed by moderator]

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u/osman_ferrari25 points·1 year ago

type 2 is the indication, weight loss is the side effect

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u/sanne_laurent10 points·1 year ago

You have restated the marketing copy. What is the actual substance here.

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u/camila_sandvik26 points·1 year ago

Yeah, glycaemic control is the original use.

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u/stablecoin_steve33 points·1 year ago

Strongly agree. A1c matters as much as weight.

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u/jonas_cardoso22 points·1 year ago

The confident tone is doing a lot of work that the evidence is not.

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u/kasper_cabrera26 points·1 year ago

hypoglycaemia risk when stacked with A1c

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u/teodor_duarte15 points·1 year ago

the 87 A1c trend is the answer

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About c/t2dglp1

Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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c/t2dglp1 rules
  1. Insulin and sulfonylurea interactions are a real hypo risk. Do not hand-wave them.
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