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c/t2dglp1·posted 11 months ago by u/camila_vasquez

small win: glycaemic control stopped being a problem at week 30

Results Cold Box ×9 Slow Clap ×2 Clean Column ×2

Something I noticed reading old threads that I have not seen said out loud.

The advice on metformin in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with the same confidence.

I have listed what I think the current consensus is below. Correct me — that is the point of posting it.

5,885 up / 2,000 down75% upvoted23 commentsid vadt0929 Aug 2025

23 comments

5 in this archive, depth 2

best — the order this archive was captured in

u/arne_nyberg444 points·11 months ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/a1c_arcMOD361 points·11 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/nils_ferreira99 points·11 months ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/ice_pack_auditcold chain268 points·11 months ago

insulin and sulfonylurea interactions are real hypo risk

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u/plain_titration220 points·11 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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About c/t2dglp1

Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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