GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Archived. This submission is more than a year old. Votes and new comments are closed, and some of the advice in it may have been superseded — check the community wiki for the current version.
2.4k
c/t2dglp1·posted 1 year ago by u/tomas_lokken

stalled for 7 weeks at 0.25mg and I refuse to panic this time

Discussion Well Actually ×8 Slow Clap ×1

Confession thread, sort of.

I went from 0.5mg to 12.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 22 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have muscle cramps I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 30 reads it before doing the same thing.

3,893 up / 1,451 down73% upvoted37 commentsid vjvfll22 Mar 2025

37 comments

15 in this archive, depth 4

best — the order this archive was captured in

u/teodor_duarte570 points·1 year ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

replysharereportpermalink
u/thandi_solberg371 points·1 year ago

the A1c change is the signal

replysharereportpermalink
u/marisol_moreau96 points·1 year ago

Did anything else change in the same window?

replysharereportpermalink
u/tomas_lokken34 points·1 year ago

A1c, CGM, stacking with metformin

replysharereportpermalink
u/neha_rahimi31 points·1 year ago

Disagree. What you are describing is consistent with hypoglycaemia, not with what you concluded.

replysharereportpermalink
u/tomas_lokkenOP395 points·1 year ago

Came off after 42 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

replysharereportpermalink
u/slow_logbook_notes30-1 point·1 year ago

Slight fix: the number was 98.7, not 98.3. Decimal point, but a fairly consequential one.

replysharereportpermalink
u/fridge_door_no391 points·1 year ago

Yeah, glycaemic control is the original use.

replysharereportpermalink
u/sock_puppet_spotter164 points·1 year ago

Not convinced. The evidence does not support that reading.

replysharereportpermalink
u/hana_lehtinen49 points·1 year ago

That is net peptide content, not purity. Different number, different meaning.

replysharereportpermalink
u/wanjiru_osei184 points·1 year ago

no medication-stopping advice, ever

replysharereportpermalink
[deleted]70 points·1 year ago

[deleted]

replysharereportpermalink
u/kian_verhoeven45 points·1 year ago

This is correct. Hypo risk is real.

replysharereportpermalink
u/bianca_demir75 points·1 year ago

the weight-loss conversation drowns out glycaemic control sometimes

replysharereportpermalink
u/nhs_waitlist_nUK19 points·1 year ago

the 78 A1c trend is the answer

replysharereportpermalink
Permalinked branches
Deep branches get their own page so a single reply chain can be linked and read on its own.
About c/t2dglp1

Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

36kmembers
62submissions
Jun 2024created
submissions / month, last year
Sponsored

PeptideMeter Analytics

Independent testing plus vendor-level trend data. Community-funded, unaffiliated.

peptidemeter.com
c/t2dglp1 rules
  1. Insulin and sulfonylurea interactions are a real hypo risk. Do not hand-wave them.
  2. Post A1c with units and the assay date.
  3. No medication-stopping advice. Ever.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Moderators
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.