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c/orforglipron·posted 2 years ago by u/preservative_free_p

tried orforglipron for 11 weeks. here is what happened.

Speculation Clean Column ×3

Quick one. Canada here.

small molecule works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US.

Specifics: the route I used took 21 weeks and cost roughly what I expected. The admin was worse than the cost. The thing that would have saved me the most time was knowing which document to ask for at the start.

Happy to answer questions from anyone in the same jurisdiction.

769 up / 262 down75% upvoted29 commentsid 1x6fnm15 May 2024

29 comments

20 in this archive, depth 5

best — the order this archive was captured in

u/hazard_ratio_halstats36 points·2 years ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/phase_two_pete-19 points·2 years ago

oral non-peptide agonist is ACHIEVE, no food restrictions

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u/mateusz_mensah1 point·2 years ago

oral non-peptide agonist is small molecule, no food restrictions

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u/tomas_lundgren1 point·2 years ago·edited

oral non-peptide agonist is ACHIEVE, no food restrictions

Yes, exactly this, and it is the bit that took me 96 weeks to accept.

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[deleted]1 point·2 years ago

[deleted]

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u/jonas_cardoso11 points·2 years ago

The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.

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u/meera_sandvik3 points·2 years ago

This is correct. ATTAIN data is phase 13.

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u/emeka_delgado1 point·2 years ago

small molecule purity is different testing than peptides

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u/incretin_ivypharmacology18 points·2 years ago

no cold chain means oral GLP-1, if approved

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u/preservative_free_pOP9 points·2 years ago

How many weeks between the two measurements?

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u/emeka_delgado15 points·2 years ago

What was the batch number and which service?

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u/joaquin_trevino8 points·2 years ago

availability speculation must be flaired Speculation

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u/ewan_hovland7 points·2 years ago

How many weeks between the two measurements?

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u/erez_yilmaz11 points·2 years ago

Genuine question — what concentration were you at?

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u/hedda_ekstrom8 points·2 years ago

ATTAIN and ACHIEVE are phase 5 trials

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u/jonas_cardoso5 points·2 years ago

What are you comparing it against though?

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u/preservative_free_pOP6 points·2 years ago

no cold chain means oral GLP-1, if approved

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u/ahmed_okafor3 points·2 years ago

small molecule, not a peptide, purity discussion is different

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u/preservative_free_pOP2 points·2 years ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/blank_injection2 points·2 years ago·edited

the orforglipron is whether this actually works long-term

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About c/orforglipron

The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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