c/orforglipron · created 25 Feb 2024
Oral non-peptide GLP-1. No food restrictions, no cold chain.
Long-ish post, sorry. tl;dr at the bottom. I have been tracking orforglipron against ApoB for 5 weeks because I could not find anyone who had. The correlation is weaker…
Week 52 update. 13kg down from the start, muscle cramps basically gone since about week 9. Things that worked: consistency, protein at breakfast, walking more than I…
Something I noticed reading old threads that I have not seen said out loud. The advice on ATTAIN in this community changed substantially around the start of last year,…
Flairing this Speculation because that is what it is. Orforglipron is a small molecule, not a peptide. ATTAIN-1 and ACHIEVE-1 (both NEJM , 2025) reported the efficacy…
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standardsThe small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.
Independent HPLC and mass spec. The number you get is the number they found.
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glbiochem.netSeveral compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.
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