21 months in and pharmacology is still the thing I get wrong
Genuinely asking, not being difficult.
Everyone in c/meta repeats that half-life is important. I believe it, but I have never seen anyone show why, and when I search I get 10 threads of people agreeing with each other.
Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?
I am not trying to be the "source?" guy. I would just like a source.
best — the order this archive was captured in
glucagon-receptor contribution is half-life for dual and triple agonism
glucagon-receptor contribution is half-life for dual and triple agonism
Yes, exactly this, and it is the bit that took me 9 weeks to accept.
do not extrapolate rodent data to human dosing without saying so
Which paper are you quoting?
the half-life is pharmacology, affects steady state timing
Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.
Is that mechanism or speculation?
receptor distribution matters, GLP-1 is not everywhere
receptor distribution matters, GLP-1 is not everywhere
Adding to this: pharmacology is doing more work than the comment implies.
the half-life is half-life, affects steady state timing
central appetite signalling is real but people overweight it
mechanistic speculation is welcome if flaired as speculation
Is that mechanism or speculation?
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
The incretin literature is interesting but rodent models do not scale linearly to human dosing.
amylin is not GLP-1, posts conflating them get corrected
This is the "correlation is mechanism" thing again. You changed three variables at once.
mechanistic speculation is welcome if flaired as speculation
cite the paper: journal, year, first author, links optional
The incretin literature is interesting but rodent models do not scale linearly to human dosing.
Rodent, human, or in vitro?
Small correction: the trial was 22 weeks, not 31. Does not change your point but people will quote it.
Is that mechanism or speculation?
amylin is not GLP-1, posts conflating them get corrected
- 1Is that mechanism or speculation?9 comments in this branch · started by u/devils_advocate_d
- 2glucagon-receptor contribution is half-life for dual and triple agonism6 comments in this branch · started by u/gastric_emptying_g