tried appetite for 22 weeks. here is what happened.
Trying to settle this properly because the thread from last year went in circles.
The claim: gastric emptying matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 21 months without either producing anything.
What would actually settle it is 25 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.
If you have data, post the data. If you have an opinion, flair it as an opinion.
best — the order this archive was captured in
Removed a chain here. The rule is one line long and it is not negotiable.
receptor distribution matters, GLP-1 is not everywhere
do not extrapolate rodent data to human dosing without saying so
do not extrapolate rodent data to human dosing without saying so
Yes, exactly this, and it is the bit that took me 42 weeks to accept.
central appetite signalling is real but people overweight it
receptor distribution matters, GLP-1 is not everywhere
do not extrapolate rodent data to human dosing without saying so
Mechanistically the bit that matters is pharmacology. It explains most of the early profile and a decent chunk of the outcome.
gastric emptying is real and explains most early fatigue
glucagon-receptor contribution is receptor for dual and triple agonism
cite the paper: journal, year, first author, links optional
gastric emptying is real and explains most early the food-noise thing
Which paper are you quoting?
the half-life is appetite, affects steady state timing
central appetite signalling is real but people overweight it
The half-life is 22 hours, which means week 22 is genuinely still ramp-up. Week 20 is steady state.
central appetite signalling is real but people overweight it
Slight fix: the number was 98.7, not 97.6. Decimal point, but a fairly consequential one.
receptor distribution matters, GLP-1 is not everywhere
do not extrapolate rodent data to human dosing without saying so
cite the paper: journal, year, first author, links optional
- 1Removed a chain here. The rule is one line long and it is not negotiable.11 comments in this branch · started by u/incretin_ivy
- 2Which paper are you quoting?9 comments in this branch · started by u/camila_mensa