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Single comment threadYou are looking at one branch of tried appetite for 22 weeks. here is what happened. — 57 comments in the full submission. View in context.
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c/glp1science·submitted 2 years ago by u/wholesome_lurker

tried appetite for 22 weeks. here is what happened.

Needs Sourcebranch of 11 comments

Trying to settle this properly because the thread from last year went in circles. The claim: gastric emptying matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 21 months without either producing anything. What would actually settle it is 25 people measuring…

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11 comments, started 2 years ago
u/incretin_ivyMOD558 points·2 years ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/wholesome_lurkerOP0 points·2 years ago

receptor distribution matters, GLP-1 is not everywhere

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u/formulary_fighterappeals1 point·2 years ago

do not extrapolate rodent data to human dosing without saying so

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u/isabela_nilsen1 point·2 years ago

do not extrapolate rodent data to human dosing without saying so

Yes, exactly this, and it is the bit that took me 42 weeks to accept.

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u/osman_eriksen1 point·2 years ago

central appetite signalling is real but people overweight it

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u/fatima_kowalski1 point·2 years ago

receptor distribution matters, GLP-1 is not everywhere

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u/lurker_for_years1 point·2 years ago

do not extrapolate rodent data to human dosing without saying so

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u/sig_figs_sammod · analytical145 points·2 years ago

Mechanistically the bit that matters is pharmacology. It explains most of the early profile and a decent chunk of the outcome.

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u/georgi_chowdhury92 points·2 years ago

gastric emptying is real and explains most early fatigue

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u/brigade_detector64 points·2 years ago

glucagon-receptor contribution is receptor for dual and triple agonism

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u/employer_carveout49 points·2 years ago

cite the paper: journal, year, first author, links optional

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About c/glp1science

The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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