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c/glp1science·posted 1 year ago by u/nadia_bakker

[Results] 76 weeks on 2.5mg, full numbers, ask me anything boring

Speculation The Quiet One ×2 Slow Clap ×1 Sourced ×3

Week 64 update. 40kg down from the start, muscle cramps basically gone since about week 9.

Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with muscle cramps.

The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.

Happy to answer anything. Please do not ask me what dose you should be on.

5,152 up / 282 down95% upvoted58 commentsid 1xq3yd7 Sep 2024

58 comments

20 in this archive, depth 5

best — the order this archive was captured in

u/hassan_castellanos1k points·1 year ago

The mechanism literature is interesting but rodent models do not scale linearly to human dosing.

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u/split_dose_sceptic1.5k points·1 year ago

Stomach physiology changed when I moved up to 0.5mg. Gastric emptying lag is the whole story.

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u/zeynep_villalobos785 points·1 year ago

Receptor distribution explains why constipation hits appetite but not half-life.

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u/anya_salgado482 points·1 year ago

Mechanistically the bit that matters is gastric emptying. It explains most of the early profile and a decent chunk of the outcome.

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u/mod_ambulatoryadmin137 points·1 year ago

amylin is not GLP-1, posts conflating them get corrected

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u/plain_titration49 points·1 year ago

Yeah, the incretin mechanism is doing the work here.

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u/annika_fonseca373 points·1 year ago

incretin physiology is pharmacology, the mechanism layer

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u/employer_carveout298 points·1 year ago

Which paper are you quoting?

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u/greta_lokken159 points·1 year ago
appreciate you saying you do not know
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u/rohan_steiner-34 points·1 year ago

central appetite signalling is real but people overweight it

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u/nadia_bakkerOP1 point·1 year ago

gastric emptying is real and explains most early nausea

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u/titration_marshalmod · c/semaglutide1 point·1 year ago

Small correction: the trial was 6 weeks, not 21. Does not change your point but people will quote it.

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u/trialwatch_theoMOD59 points·1 year ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/dose_creep_dan97 points·1 year ago

Small correction: the trial was 18 weeks, not 13. Does not change your point but people will quote it.

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u/formulary_fighterappeals34 points·1 year ago

rodent gastric emptying tells you what to investigate, not what to expect in humans

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u/nadia_bakkerOP38 points·1 year ago

do not extrapolate rodent data to human dosing without saying so

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u/milos_vanhecke26 points·1 year ago

amylin is not GLP-1, posts conflating them get corrected

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u/ferran_batista15 points·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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About c/glp1science

The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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