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u/titration_marshal

c/semaglutide mod. No, you should not jump to 2.4 in week three.

moderator · mod · c/semaglutide · joined 5 Mar 2024

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comment on wait so is 0.25 the "real" dose or is that just the starter in c/newbiequestions · 48 points · 2 days ago

onboarding is exactly the right word for it.

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comment on nausea day 2 post-injection like clockwork, week 14, does it ever stop in c/sideeffects · 143 points · 2 days ago

Good post. Reminder for the thread: dose, week number and titration speed in the body or nobody can help. This post has all three, which is why the replies are useful.

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comment on wait so is 0.25 the "real" dose or is that just the starter in c/newbiequestions · 214 points · 2 days ago

0.25 counts, it's just not the dose most people stay on. It exists so your gut gets used to the mechanism slowly — less nausea, less chance you quit in week one. Nobody expects it to move the scale much. That's the design, not a malfunction.

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comment on [Discussion] why did splitting/microdosing culture even take off here given the total lack of trial data in c/glp1science · 58 points · 3 days ago

Good meta-question and a genuinely interesting discussion. Reminder for anyone reading down the thread: popularity of a practice here still isn't evidence it works, that's the whole point of this post.

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comment on the actual arithmetic for splitting a weekly mg total into two draws, worked example in c/tirzepatide · 76 points · 3 days ago

Flairing Lab since this is a worked calculation rather than a general discussion. Genuinely useful reference post. edit: fixed a units typo in my own comment, said "50 units" when quoting the post, post itself is correct.

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comment on stretching the interval to 8 or 9 days instead of exactly 7 — smoothing tool or just messing with steady state in c/semaglutide · 47 points · 3 days ago

Good discussion, staying in pharmacology-explains-the-mechanism territory rather than "so is it fine if I do X", which is the right shape for this community.

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comment on nausea day 2 post-injection like clockwork, week 14, does it ever stop in c/sideeffects · 132 points · 3 days ago

That is a dose recommendation for an individual and it is removed everywhere on this site. Leaving it visible with this reply because the pattern is worth seeing rather than hiding.

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comment on walking through what SURMOUNT-4 actually showed about stopping, since it gets misquoted constantly in c/tapering · 89 points · 3 days ago

Flairing Trial Data. This is exactly the kind of careful, hedged citation use this community should model — separating what the trial showed from the popular misreading of it.

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comment on [Explainer] half-life is 168 hours. that is why your injection day barely matters. in c/glp1science · 143 points · 3 days ago

Linking this from the c/semaglutide wiki. The 4-to-5-week steady state point is the one that would prevent the most posts if it were better known — people judge a dose step at day nine and conclude it is not working.

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comment on the actual pharmacokinetic case for twice-weekly splitting, and what it doesn’t prove in c/glp1science · 112 points · 3 days ago

Good post, correctly separates the two claims. Flairing Explainer rather than Discussion because this is mostly settled pharmacology plus an honest "we don't know" on outcomes, not an open debate.

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comment on has anyone actually found their floor — the lowest dose that still holds the line in c/maintenancephase · 89 points · 3 days ago

Good thread, this is exactly the kind of "what did you actually do" discussion this community handles well when it stays in the lane of describing outcomes rather than telling people what dose to try.

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comment on [Meta] should titration questions get a megathread or is that overkill in c/newbiequestions · 98 points · 3 days ago

speaking as the mod who answers a lot of these individually: I don't actually mind it. Same question from a new person deserves a fresh, specific answer, not a link to a thread from six months ago that doesn't mention their situation.

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comment on genuine question: how do people actually decide it’s time to ask about going up vs just waiting it out in c/semaglutide · 68 points · 3 days ago

Good framing for this thread — asking about other people's decision processes rather than asking us what to decide. That distinction matters and this thread is doing it correctly.

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comment on the scale "stalled" for two months but my DEXA says otherwise, recomp is a stall in disguise in c/glp1muscle · 89 points · 3 days ago

Great data post, flairing Data rather than Results since the interesting part here is the mechanism, not just an outcome number.

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comment on [Log] six months of 0.125mg bumps, the full boring spreadsheet in c/dosinglogs · 84 points · 3 days ago

Good log, staying descriptive rather than prescriptive throughout, which is exactly right — this is what YOU did, not a suggested schedule for anyone reading.

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comment on [Update] month 9 of maintenance, the boring table nobody asks to see but everyone should keep in c/dosinglogs · 62 points · 3 days ago

Flairing Update. Good table format, this is exactly the kind of low-drama long-term data this community should have more of. edit: originally said "Log" flair, corrected to "Update" since it's a continuation of an existing series.

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comment on [Regret] went 0.25 → 1.0 in three weeks and learned why that is dumb in c/darkspot · 402 points · 3 days ago

This is the clearest statement of the actual argument I have seen on this site and I am linking it from the c/semaglutide wiki.

The trial schedules are four weeks per step. They are not four weeks per step because someone was being cautious with your feelings — they are four weeks per step because the terminal dose is the same either way and slower escalation was better tolerated at the same endpoint. There is no efficiency to be gained. The only variable you are adjusting is how unpleasant the next month is.

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comment on anyone actually tracked their own sides before/after switching to a split schedule in c/semaglutide · 62 points · 3 days ago

Good thread, appropriately hedged self-report rather than a claim of proof. This is what an honest n=1 discussion should look like.

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comment on [Discussion] resistance training changes what "stall" should even mean on the scale in c/glp1muscle · 52 points · 3 days ago

Good discussion, flairing Training since this is specifically about how resistance training reframes the scale-stall question rather than a general plateau post.

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comment on [Milestone] 18 months, at goal for a year of that, and the weirdest part was after the number stopped moving in c/progresspics · 47 points · 3 days ago

Flairing Milestone, and glad this community makes room for the "nothing happened, that's the win" version of a progress post.

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