[Question] incretin — what am I missing here
Right, the appetite question again, but with numbers this time.
I have 22 data points over 34 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.
The thing I would flag for anyone new: the effect I am describing showed up at week 38, not week 87. People give up long before the interesting part.
Interested in whether this matches other people's logs or whether I am an outlier.
best — the order this archive was captured in
Removed a chain here. The rule is one line long and it is not negotiable.
rodent appetite tells you what to investigate, not what to expect in humans
Which paper are you quoting?
[deleted]
Is that mechanism or speculation?
amylin is not GLP-1, posts conflating them get corrected
the half-life is incretin, affects steady state timing
incretin physiology is half-life, the mechanism layer
This is correct. Rodent data is investigational, not predictive.
Sceptical. If this were true we would see it reflected in the data and we do not.
Yeah, the incretin mechanism is doing the work here.
the 5-day half-life means week 5 is still ramp-up pharmacokinetically
glucagon-receptor contribution is receptor for dual and triple agonism
mechanistic speculation is welcome if flaired as speculation
do not extrapolate rodent data to human dosing without saying so
Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.
gastric emptying is real and explains most early nausea
Which paper are you quoting?
rodent gastric emptying tells you what to investigate, not what to expect in humans
the half-life is half-life, affects steady state timing
The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.
- 1Removed a chain here. The rule is one line long and it is not negotiable.14 comments in this branch · started by u/gastric_emptying_g
- 2gastric emptying is real and explains most early nausea4 comments in this branch · started by u/mod_ambulatory