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c/glp1science·submitted 2 years ago by u/flair_enthusiast

[Question] incretin — what am I missing here

Questionbranch of 14 comments

Right, the appetite question again, but with numbers this time. I have 22 data points over 34 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…

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14 comments, started 2 years ago
u/gastric_emptying_gMOD330 points·2 years ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/lurker_for_years0 points·2 years ago

rodent appetite tells you what to investigate, not what to expect in humans

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u/enzo_danquah1 point·2 years ago

Which paper are you quoting?

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[deleted]1 point·2 years ago

[deleted]

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u/hassan_castellanos1 point·2 years ago

Is that mechanism or speculation?

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u/formulary_fighterappeals1 point·2 years ago

amylin is not GLP-1, posts conflating them get corrected

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u/niels_roos109 points·2 years ago

the half-life is incretin, affects steady state timing

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u/emeka_chowdhury129 points·2 years ago

incretin physiology is half-life, the mechanism layer

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u/gastric_emptying_g156 points·2 years ago

This is correct. Rodent data is investigational, not predictive.

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u/rasmus_kimani42 points·2 years ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/ferran_dahlberg238 points·2 years ago

Yeah, the incretin mechanism is doing the work here.

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u/sanne_delgado185 points·2 years ago·edited

the 5-day half-life means week 5 is still ramp-up pharmacokinetically

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u/lina_ndiaye221 points·2 years ago

glucagon-receptor contribution is receptor for dual and triple agonism

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u/flair_enthusiastOP82 points·2 years ago

mechanistic speculation is welcome if flaired as speculation

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