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c/glp1science·posted 2 years ago by u/elin_lundgren

Denmark: incretin, and what it actually costs here

Explainer Clean Column ×1 The Quiet One ×3 Cold Box ×3

Week 70 update. 31kg down from the start, muscle cramps basically gone since about week 27.

Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with muscle cramps.

The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.

Happy to answer anything. Please do not ask me what dose you should be on.

15,526 up / 5,601 down73% upvoted32 commentsid 1y9i1525 Dec 2023

32 comments

12 in this archive, depth 5

best — the order this archive was captured in

u/hassan_ostergaard1.2k points·2 years ago

Yeah, the incretin mechanism is doing the work here.

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u/osman_eriksen862 points·2 years ago

Is that mechanism or speculation?

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u/bastian_eriksen712 points·2 years ago

Rodent, human, or in vitro?

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u/elin_lundgrenOP364 points·2 years ago

Receptor distribution explains why muscle cramps hits pharmacology but not mechanism.

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u/ferran_dahlberg276 points·2 years ago

Yeah, the incretin mechanism is doing the work here.

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u/elin_lundgrenOP139 points·2 years ago

Strongly agree. Central appetite is real but people overstate it.

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u/the_poster_in_question_2026340 points·2 years ago·edited

gastric emptying is real and explains most early nausea

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u/rafael_ostergaard281 points·2 years ago

amylin is not GLP-1, posts conflating them get corrected

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u/elin_lundgrenOP156 points·2 years ago

receptor distribution matters, GLP-1 is not everywhere

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u/fatima_kowalski605 points·2 years ago

mechanistic speculation is welcome if flaired as speculation

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u/incretin_ivyMOD324 points·2 years ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/kavya_kravchenko0 points·2 years ago

This is correct. Rodent data is investigational, not predictive.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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