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c/glp1science·submitted 2 years ago by u/elin_lundgren

Denmark: incretin, and what it actually costs here

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Week 70 update. 31kg down from the start, muscle cramps basically gone since about week 27. Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with muscle cramps. The part that surprised me is how much of this is admin.…

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8 comments, started 2 years ago
u/osman_eriksen862 points·2 years ago

Is that mechanism or speculation?

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u/bastian_eriksen712 points·2 years ago

Rodent, human, or in vitro?

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u/elin_lundgrenOP364 points·2 years ago

Receptor distribution explains why muscle cramps hits pharmacology but not mechanism.

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u/ferran_dahlberg276 points·2 years ago

Yeah, the incretin mechanism is doing the work here.

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u/elin_lundgrenOP139 points·2 years ago

Strongly agree. Central appetite is real but people overstate it.

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u/the_poster_in_question_2026340 points·2 years ago·edited

gastric emptying is real and explains most early nausea

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u/rafael_ostergaard281 points·2 years ago

amylin is not GLP-1, posts conflating them get corrected

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u/elin_lundgrenOP156 points·2 years ago

receptor distribution matters, GLP-1 is not everywhere

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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