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c/glp1science·submitted 1 year ago by u/nadia_bakker

[Results] 76 weeks on 2.5mg, full numbers, ask me anything boring

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Week 64 update. 40kg down from the start, muscle cramps basically gone since about week 9. Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with muscle cramps. The part that surprised me is how much of this is admin.…

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5 comments, started 1 year ago
u/anya_salgado482 points·1 year ago

Mechanistically the bit that matters is gastric emptying. It explains most of the early profile and a decent chunk of the outcome.

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u/mod_ambulatoryadmin137 points·1 year ago

amylin is not GLP-1, posts conflating them get corrected

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u/plain_titration49 points·1 year ago

Yeah, the incretin mechanism is doing the work here.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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