GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Single comment threadYou are looking at one branch of tried appetite for 22 weeks. here is what happened. — 57 comments in the full submission. View in context.
4.4k
c/glp1science·submitted 2 years ago by u/wholesome_lurker

tried appetite for 22 weeks. here is what happened.

Needs Sourcebranch of 9 comments

Trying to settle this properly because the thread from last year went in circles. The claim: gastric emptying matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 21 months without either producing anything. What would actually settle it is 25 people measuring…

Read the full submission and all 57 comments →

This branch

9 comments, started 2 years ago
u/camila_mensa176 points·2 years ago

Which paper are you quoting?

replysharereportpermalink
u/wholesome_lurker0 points·2 years ago

the half-life is appetite, affects steady state timing

replysharereportpermalink
u/enzo_petrescu1 point·2 years ago

central appetite signalling is real but people overweight it

replysharereportpermalink
u/wholesome_lurkerOP1 point·2 years ago

The half-life is 22 hours, which means week 22 is genuinely still ramp-up. Week 20 is steady state.

replysharereportpermalink
u/karma_irrelevant1 point·2 years ago·edited

central appetite signalling is real but people overweight it

replysharereportpermalink
u/gradient_goblin1 point·2 years ago

Slight fix: the number was 98.7, not 97.6. Decimal point, but a fairly consequential one.

replysharereportpermalink
u/titration_marshalmod · c/semaglutide1 point·2 years ago

receptor distribution matters, GLP-1 is not everywhere

replysharereportpermalink
u/osman_eriksen1 point·2 years ago·edited

do not extrapolate rodent data to human dosing without saying so

replysharereportpermalink
u/anya_salgado1 point·2 years ago·edited

cite the paper: journal, year, first author, links optional

replysharereportpermalink

← back to the whole thread

About c/glp1science

The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

50kmembers
95submissions
Oct 2023created
submissions / month, last year
Sponsored

PeptideMeter Analytics

Independent testing plus vendor-level trend data. Community-funded, unaffiliated.

peptidemeter.com
More in c/glp1science
c/glp1science rules
  1. Cite the paper: journal, year, first author. Links optional, citation mandatory.
  2. Mechanistic speculation is welcome if flaired as speculation.
  3. No extrapolating rodent data to human dosing without saying that is what you are doing.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Full rules and how they are enforced →
Moderators
u/incretin_ivyu/trialwatch_theou/gastric_emptying_gu/sig_figs_sam
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.

Full disclaimer →