u/aksel_palacios
Contributes reviews on supplier material. Based in Dhaka.
member · joined 15 Jun 2025
comment on why does GIP agonism seem to reduce nausea rather than add to it in c/glp1science · 10 points · 7 days ago
Yeah, the incretin mechanism is doing the work here.
comment on bought a second-hand HPLC. worst best decision of my life. AMA in c/hplc · 1 points · 9 days ago
chromatogram or it did not happen
comment on [PSA] Canada is not what most of this community thinks it is in c/glp1canada · 0 points · 13 days ago
Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.
comment on [Lab] LC-MS confirmed identity but the UV purity is 94%. now what in c/hplc · 8 points · 16 days ago
instrument quality is less important than analyst consistency
comment on does special authorization actually matter or is it forum lore at this point in c/glp1canada · 5 points · 19 days ago
Disagree but this is the good kind of wrong — it is specific enough to be checked.
comment on does gradient actually matter or is it forum lore at this point in c/hplc · 16 points · 1 months ago
axis labels included, always
comment on [Question] Ireland — has anyone got a straight answer on gastric emptying in c/glp1science · 0 points · 2 months ago
amylin is not GLP-1, posts conflating them get corrected
comment on what would you tell week-1 you about HPLC in c/hplc · 189 points · 2 months ago
chromatogram or it did not happen
comment on 6 months in and gradient is still the thing I get wrong in c/hplc · 28 points · 3 months ago
a round-robin on baseline integration would be genuinely useful
Disagree on that part. 99.0% and 98.9% on the same vial is normal.
comment on [Question] method development — what am I missing here in c/hplc · 4 points · 3 months ago
What was the column and what gradient?
comment on [Results] 87 weeks, 25kg, and special authorization was the hard part in c/glp1canada · -9 points · 3 months ago
the 13 province variation is real
comment on [Meta] proposal — a flair for pharmacology posts in c/glp1science · 38 points · 3 months ago
This is correct. Rodent data is investigational, not predictive.
comment on three years of integration threads, summarised so you do not have to read them in c/hplc · 43 points · 4 months ago
The related substances profile is way more interesting than the main peak %. A 98% with 7 peaks is different from a 98% that is one 16% impurity.
comment on the half-life question that gets asked weekly, answered properly in c/glp1science · 33 points · 5 months ago
the half-life is incretin, affects steady state timing
Disagree on that part. 98.7% and 98.3% on the same vial is normal.
comment on reading receptor threads from 2024 and half of it aged badly in c/glp1science · 86 points · 6 months ago
the 4-day half-life means week 4 is still ramp-up pharmacokinetically
comment on LC-MS: what the trials say vs what this community says in c/hplc · 21 points · 6 months ago
Not convinced. The evidence does not support that reading.
comment on 21 months in and pharmacology is still the thing I get wrong in c/glp1science · 11 points · 6 months ago
Small correction: the trial was 22 weeks, not 31. Does not change your point but people will quote it.
comment on tried HPLC for 20 weeks. here is what happened. in c/hplc · 6 points · 6 months ago
Did they post the raw trace or just the summary?
comment on [Vendor] WXT order #13 — Germany, 19 days, no drama, receipts inside in c/glp1canada · 21 points · 7 months ago
Has anyone actually got this in writing, or is it forum lore at this point?
comment on [Results] 67 weeks, 26kg, and gradient was the hard part in c/hplc · 1 points · 8 months ago
related substances are where the story lives, not the main peak