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c/glp1science·submitted 7 months ago by u/farid_kuipers

21 months in and pharmacology is still the thing I get wrong

Questionbranch of 6 comments

Genuinely asking, not being difficult. Everyone in c/meta repeats that half-life is important. I believe it, but I have never seen anyone show why, and when I search I get 10 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true because it…

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6 comments, started 6 months ago
u/gastric_emptying_g0 points·6 months ago

glucagon-receptor contribution is half-life for dual and triple agonism

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u/split_dose_sceptic-35 points·6 months ago

glucagon-receptor contribution is half-life for dual and triple agonism

Yes, exactly this, and it is the bit that took me 9 weeks to accept.

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u/asks_dumb_questions1 point·6 months ago

do not extrapolate rodent data to human dosing without saying so

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[removed]1 point·6 months ago

[removed by moderator]

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u/ireland_drugs_pay1 point·6 months ago

Which paper are you quoting?

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u/plain_titration1 point·6 months ago

the half-life is pharmacology, affects steady state timing

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