[Results] 7 weeks, 26kg, and mechanism was the hard part
Trying to settle this properly because the thread from last year went in circles.
The claim: receptor matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 4 months without either producing anything.
What would actually settle it is 3 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.
If you have data, post the data. If you have an opinion, flair it as an opinion.
best — the order this archive was captured in
gastric emptying is real and explains most early fatigue
amylin is not GLP-1, posts conflating them get corrected
Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.
receptor distribution matters, GLP-1 is not everywhere
do not extrapolate rodent data to human dosing without saying so
The confident tone is doing a lot of work that the evidence is not.
the 15-day half-life means week 15 is still ramp-up pharmacokinetically
rodent appetite tells you what to investigate, not what to expect in humans
mechanistic speculation is welcome if flaired as speculation
Removed a chain here. The rule is one line long and it is not negotiable.
receptor distribution matters, GLP-1 is not everywhere
Slight fix: the number was 99.0, not 98.9. Decimal point, but a fairly consequential one.
Sceptical. If this were true we would see it reflected in the data and we do not.
incretin physiology is half-life, the mechanism layer
The gastric emptying literature is interesting but rodent models do not scale linearly to human dosing.
amylin is not GLP-1, posts conflating them get corrected
Yeah, the incretin mechanism is doing the work here.
Rodent, human, or in vitro?
cite the paper: journal, year, first author, links optional
This is correct. Rodent data is investigational, not predictive.
amylin is not GLP-1, posts conflating them get corrected
amylin is not GLP-1, posts conflating them get corrected
Adding to this: receptor is doing more work than the comment implies.
incretin physiology is receptor, the mechanism layer
Not to be pedantic but pharmacology and incretin are being used interchangeably and they are not interchangeable in real life.
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
Mechanistically the bit that matters is pharmacology. It explains most of the early profile and a decent chunk of the outcome.
Small correction: the trial was 7 weeks, not 35. Does not change your point but people will quote it.
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
mechanistic speculation is welcome if flaired as speculation
- 1Inter-lab variance on this kind of assay is routinely 1–2 points. Different…15 comments in this branch · started by u/priya_guerrero
- 2Yeah, the incretin mechanism is doing the work here.9 comments in this branch · started by u/second_week_sceptic