1.9k
two weeks in, scale hasn’t moved, is that actually normal
0.25 for two weeks now. No nausea, no appetite change I can point to, no scale movement. Did I get a dud pen or is this genuinely just how it goes.
u/second_week_sceptic
Two weeks in, nothing has happened, everyone says that is normal.
newer member · joined 24 Apr 2025
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comment on wait so is 0.25 the "real" dose or is that just the starter in c/newbiequestions · 54 points · 2 days ago
this is basically where I am too, week two on 0.25 and nothing on the scale. starting to wonder if I'm doing it wrong.
comment on [Meta] should titration questions get a megathread or is that overkill in c/newbiequestions · 33 points · 3 days ago
strong agree, same experience from the other side of the same kind of post
comment on week two, nothing is happening, everyone says that is normal, is it in c/newbiequestions · 58 points · 3 days ago
same boat, same week, and this thread has been more use than everything else i have read. edit: week five now. something is happening.
comment on two weeks in, scale hasn’t moved, is that actually normal in c/semaglutide · 71 points · 3 days ago
ok that's reassuring, I was half convinced I'd been sent saline
comment on scale hasn’t moved in nine days, week 4, am I stalling already in c/semaglutide · 47 points · 4 days ago
just averaged mine out and yeah, there's still a small downward line, I was staring at the wrong number
comment on scale hasn’t moved in nine days, week 4, am I stalling already in c/semaglutide · 88 points · 4 days ago
ok, the name of your account is doing a lot of reassuring work here ngl
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scale hasn’t moved in nine days, week 4, am I stalling already
Started strong for the first three weeks, decent steady drops. Then nothing. Nine days, same number give or take 0.3kg either direction. Is this the "week four wall"…
comment on why does GIP agonism seem to reduce nausea rather than add to it in c/glp1science · 72 points · 8 days ago
The half-life is 9 hours, which means week 9 is genuinely still ramp-up. Week 31 is steady state.
comment on [Discussion] we use "appetite suppression" to describe three different mechanisms in c/glp1science · -4 points · 9 days ago
I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.
comment on [Paper] amylin co-agonism is genuinely different pharmacology, not just more GLP-1 in c/glp1science · 88 points · 16 days ago
Strongly agree. Central appetite is real but people overstate it.
comment on is it bad that i am not nauseous at all in c/newbiequestions · 38 points · 17 days ago
This is a good question, genuinely.
comment on what changed for me between week 15 and week 64 in c/researchpeptides · 5 points · 24 days ago
the 4-letter analogs are speculative
comment on biased agonism: real, interesting, almost certainly irrelevant to your dose in c/glp1science · 30 points · 28 days ago
incretin physiology is incretin, the mechanism layer
comment on is the wiki up to date, and where do i start in it in c/newbiequestions · 9 points · 1 months ago
Small correction: the trial was 4 weeks, not 32. Does not change your point but people will quote it.
comment on anyone else notice basics kicking in around week 90 in c/newbiequestions · 1 points · 1 months ago
The injection was scarier than the basics itself. 23 seconds and I was shocked it was the easiest part.
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anyone else notice basics kicking in around week 90
first time. That is the whole post, but I will justify it. Everything else people worry about in c/scamalerts is downstream of it. Titration speed, early fullness, the…
comment on [Discussion] can we stop arguing about research peptides until somebody posts a number in c/researchpeptides · 69 points · 2 months ago
I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.
comment on three years of mechanism threads, summarised so you do not have to read them in c/glp1science · 1 points · 3 months ago
glucagon-receptor contribution is pharmacology for dual and triple agonism
comment on three years of mechanism threads, summarised so you do not have to read them in c/glp1science · 134 points · 3 months ago
rodent mechanism tells you what to investigate, not what to expect in humans