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[Discussion] appetite return is doing more work than we give it credit for
Genuinely asking, not being difficult. Everyone in c/bloodwork repeats that interval stretching is important. I believe it, but I have never seen anyone show why, and…
u/ismael_eriksen
Contributes reviews on supplier material. Based in Braga.
member · joined 15 Jun 2025
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comment on reta phase 2 was -24.2% at 48 weeks and people quote it like it is a maintenance number in c/retatrutide · 85 points · 2 days ago
The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.
comment on [Lab] two reta batches, two services, 98.4% and 97.9% in c/retatrutide · -20 points · 3 days ago
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
comment on [Paper] receptor distribution and why the GI effects were predictable in c/glp1science · 1 points · 5 days ago
Yeah, the incretin mechanism is doing the work here.
comment on is anyone tracking heart rate properly on reta or are we all guessing in c/retatrutide · 32 points · 5 days ago
nobody should be giving this to anyone without extensive monitoring
comment on [Explainer] HOMA-IR is crude and free, track it anyway in c/bloodwork · 1 points · 8 days ago
eGFR noise on rapid loss is real.
Disagree on that part. 97.9% and 97.6% on the same vial is normal.
comment on the dose escalation thing finally clicked for me and I want to write it down in c/retatrutide · 14 points · 18 days ago
Slight fix: the number was 97.6, not 97.9. Decimal point, but a fairly consequential one.
comment on [Explainer] which labs are worth repeating quarterly and which are theatre in c/bloodwork · 2 points · 21 days ago
baseline is the most important A1c measurement, you cannot collect it later
comment on [Explainer] which labs are worth repeating quarterly and which are theatre in c/bloodwork · 11 points · 22 days ago
Yeah, baseline matters more than any later number.
comment on [Explainer] why an oral non-peptide escapes the absorption problem entirely in c/glp1science · 15 points · 24 days ago
glucagon-receptor contribution is half-life for dual and triple agonism
comment on [Explainer] why an oral non-peptide escapes the absorption problem entirely in c/glp1science · 110 points · 25 days ago
Where does the incretin data actually come from?
comment on [Discussion] TRIUMPH is doing more work than we give it credit for in c/retatrutide · 1 points · 1 months ago
phase 2 numbers are not maintenance numbers, cite the trial
comment on interval stretching is the most under-discussed thing in c/progresspics in c/tapering · 34 points · 1 months ago
Not to be pedantic but discontinuation and appetite return are being used interchangeably and they are not interchangeable in real life.
comment on week 76 check-in — 26kg down, fatigue manageable, one thing confusing me in c/bloodwork · 2 points · 1 months ago
Is that fasted?
comment on [Discussion] appetite return is doing more work than we give it credit for in c/tapering · 4 points · 1 months ago
Week 69 for me and the honest summary is: 42kg down, nausea manageable, and I have thought about food maybe four times today.
comment on [Discussion] appetite return is doing more work than we give it credit for in c/tapering · 44 points · 1 months ago
Came off after 69 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.
comment on help me understand A1c, I have read the wiki twice in c/bloodwork · 35 points · 1 months ago
nobody here can tell you what a result means for you
comment on [Milestone] came off two blood pressure meds and one statin in c/progresspics · 82 points · 1 months ago
Disagree but this is the good kind of wrong — it is specific enough to be checked.
comment on the water content question that gets asked weekly, answered properly in c/coa · 69 points · 1 months ago
chromatogram or it did not happen
comment on [Results] 90 weeks, full dose-and-weight table, ask me anything in c/progresspics · 7 points · 1 months ago
Respectfully this is a sample of one presented as a finding.