[Results] 7 weeks, 26kg, and mechanism was the hard part
Trying to settle this properly because the thread from last year went in circles. The claim: receptor matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 4 months without either producing anything. What would actually settle it is 3 people measuring the same…
Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.
receptor distribution matters, GLP-1 is not everywhere
do not extrapolate rodent data to human dosing without saying so
The confident tone is doing a lot of work that the evidence is not.
the 15-day half-life means week 15 is still ramp-up pharmacokinetically
rodent appetite tells you what to investigate, not what to expect in humans
mechanistic speculation is welcome if flaired as speculation
Removed a chain here. The rule is one line long and it is not negotiable.
receptor distribution matters, GLP-1 is not everywhere
Slight fix: the number was 99.0, not 98.9. Decimal point, but a fairly consequential one.
Sceptical. If this were true we would see it reflected in the data and we do not.
incretin physiology is half-life, the mechanism layer
The gastric emptying literature is interesting but rodent models do not scale linearly to human dosing.
amylin is not GLP-1, posts conflating them get corrected