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c/glp1science·submitted 1 year ago by u/split_dose_sceptic

[Results] 7 weeks, 26kg, and mechanism was the hard part

Questionbranch of 9 comments

Trying to settle this properly because the thread from last year went in circles. The claim: receptor matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 4 months without either producing anything. What would actually settle it is 3 people measuring the same…

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9 comments, started 1 year ago
u/second_week_sceptic300 points·1 year ago·edited

Yeah, the incretin mechanism is doing the work here.

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u/neha_krastev144 points·1 year ago

Rodent, human, or in vitro?

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u/devils_advocate_d72 points·1 year ago

cite the paper: journal, year, first author, links optional

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u/analog_alphabet60 points·1 year ago

This is correct. Rodent data is investigational, not predictive.

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u/gradient_goblin219 points·1 year ago

amylin is not GLP-1, posts conflating them get corrected

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u/aa_analysis_andy60 points·1 year ago

amylin is not GLP-1, posts conflating them get corrected

Adding to this: receptor is doing more work than the comment implies.

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u/priya_guerrero18 points·1 year ago·edited

incretin physiology is receptor, the mechanism layer

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u/vikram_mbeki51 points·1 year ago

Not to be pedantic but pharmacology and incretin are being used interchangeably and they are not interchangeable in real life.

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u/incretin_ivypharmacology245 points·1 year ago·edited

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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