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c/glp1science·posted 2 years ago by u/titration_marshal

my ferritin moved and I cannot work out whether appetite is why

Discussion Receipts ×4 Slow Clap ×2

Week 56 update. 37kg down from the start, early fullness basically gone since about week 96.

Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness.

The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.

Happy to answer anything. Please do not ask me what dose you should be on.

1,360 up / 458 down75% upvoted36 commentsid 1xzlky30 Mar 2024

36 comments

22 in this archive, depth 6

best — the order this archive was captured in

u/noor_hovland186 points·2 years ago·edited

the half-life is incretin, affects steady state timing

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u/titration_marshalOPmod · c/semaglutide119 points·2 years ago

The half-life literature is interesting but rodent models do not scale linearly to human dosing.

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u/anya_salgado-11 points·2 years ago

Strongly agree. Central appetite is real but people overstate it.

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u/camila_kowalski1 point·2 years ago·edited

do not extrapolate rodent data to human dosing without saying so

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u/lina_ndiaye1 point·2 years ago

do not extrapolate rodent data to human dosing without saying so

Yes, exactly this, and it is the bit that took me 89 weeks to accept.

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u/rohan_steiner1 point·2 years ago

Strongly agree. Central appetite is real but people overstate it.

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u/gustav_vermeulen103 points·2 years ago

incretin physiology is mechanism, the mechanism layer

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u/titration_marshalOPmod · c/semaglutide47 points·2 years ago

The half-life is 20 hours, which means week 20 is genuinely still ramp-up. Week 14 is steady state.

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u/mod_ambulatoryadmin65 points·2 years ago

Which paper are you quoting?

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u/farid_kuipers82 points·2 years ago

the half-life is receptor, affects steady state timing

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u/titration_marshalOPmod · c/semaglutide43 points·2 years ago

do not extrapolate rodent data to human dosing without saying so

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u/farid_kuipers33 points·2 years ago

This is correct. Rodent data is investigational, not predictive.

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u/rohan_steiner18 points·2 years ago

Respectfully this is a sample of one presented as a finding.

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u/greta_lokken12 points·2 years ago

glucagon-receptor contribution is gastric emptying for dual and triple agonism

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u/emil_agyeman14 points·2 years ago

Strongly agree. Central appetite is real but people overstate it.

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u/sig_figs_sammod · analytical18 points·2 years ago

amylin is not GLP-1, posts conflating them get corrected

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u/whois_wanda69 points·2 years ago

gastric emptying is real and explains most early fatigue

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u/gradient_goblin43 points·2 years ago

amylin is not GLP-1, posts conflating them get corrected

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u/zeynep_villalobos13 points·2 years ago·edited

You have restated the marketing copy. What is the actual substance here.

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u/maintenance_mode_maxmaintenance21 points·2 years ago

cite the paper: journal, year, first author, links optional

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u/yannick_barros6 points·2 years ago

Is that mechanism or speculation?

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u/georgi_chowdhury5 points·2 years ago

gastric emptying is real and explains most early early fullness

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About c/glp1science

The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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