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Single comment threadYou are looking at one branch of my ferritin moved and I cannot work out whether appetite is why — 36 comments in the full submission. View in context.
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c/glp1science·submitted 2 years ago by u/titration_marshal

my ferritin moved and I cannot work out whether appetite is why

Discussionbranch of 6 comments

Week 56 update. 37kg down from the start, early fullness basically gone since about week 96. Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness. The part that surprised me is how much of this is…

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6 comments, started 2 years ago
u/noor_hovland186 points·2 years ago·edited

the half-life is incretin, affects steady state timing

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u/titration_marshalOPmod · c/semaglutide119 points·2 years ago

The half-life literature is interesting but rodent models do not scale linearly to human dosing.

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u/anya_salgado-11 points·2 years ago

Strongly agree. Central appetite is real but people overstate it.

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u/camila_kowalski1 point·2 years ago·edited

do not extrapolate rodent data to human dosing without saying so

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u/lina_ndiaye1 point·2 years ago

do not extrapolate rodent data to human dosing without saying so

Yes, exactly this, and it is the bit that took me 89 weeks to accept.

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u/rohan_steiner1 point·2 years ago

Strongly agree. Central appetite is real but people overstate it.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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