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Single comment threadYou are looking at one branch of my ferritin moved and I cannot work out whether appetite is why — 36 comments in the full submission. View in context.
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c/glp1science·submitted 2 years ago by u/titration_marshal

my ferritin moved and I cannot work out whether appetite is why

Discussionbranch of 16 comments

Week 56 update. 37kg down from the start, early fullness basically gone since about week 96. Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness. The part that surprised me is how much of this is…

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This branch

16 comments, started 2 years ago
u/gustav_vermeulen103 points·2 years ago

incretin physiology is mechanism, the mechanism layer

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u/titration_marshalOPmod · c/semaglutide47 points·2 years ago

The half-life is 20 hours, which means week 20 is genuinely still ramp-up. Week 14 is steady state.

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u/mod_ambulatoryadmin65 points·2 years ago

Which paper are you quoting?

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u/farid_kuipers82 points·2 years ago

the half-life is receptor, affects steady state timing

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u/titration_marshalOPmod · c/semaglutide43 points·2 years ago

do not extrapolate rodent data to human dosing without saying so

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u/farid_kuipers33 points·2 years ago

This is correct. Rodent data is investigational, not predictive.

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u/rohan_steiner18 points·2 years ago

Respectfully this is a sample of one presented as a finding.

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u/greta_lokken12 points·2 years ago

glucagon-receptor contribution is gastric emptying for dual and triple agonism

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u/emil_agyeman14 points·2 years ago

Strongly agree. Central appetite is real but people overstate it.

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u/sig_figs_sammod · analytical18 points·2 years ago

amylin is not GLP-1, posts conflating them get corrected

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u/whois_wanda69 points·2 years ago

gastric emptying is real and explains most early fatigue

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u/gradient_goblin43 points·2 years ago

amylin is not GLP-1, posts conflating them get corrected

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u/zeynep_villalobos13 points·2 years ago·edited

You have restated the marketing copy. What is the actual substance here.

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u/maintenance_mode_maxmaintenance21 points·2 years ago

cite the paper: journal, year, first author, links optional

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u/yannick_barros6 points·2 years ago

Is that mechanism or speculation?

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u/georgi_chowdhury5 points·2 years ago

gastric emptying is real and explains most early early fullness

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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