the co-agonism question that gets asked weekly, answered properly
Long-ish post, sorry. tl;dr at the bottom.
I have been tracking cagrilintide against eGFR for 15 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.
Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.
tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.
best — the order this archive was captured in
Rodent or human data?
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
amylin receptor distribution is different from GLP-1
Small correction: the trial was 16 weeks, not 26. Does not change your point but people will quote it.
This is correct. The co-agonism is real.
REDEFINE readouts are phase 8 data
long-acting amylin is co-agonism, different satiety profile
REDEFINE phase 3 readouts are interesting but 3 person satiety is different from 3 trial satiety.
the mechanism is different, the side effect profile reflects it
Yeah, amylin is doing different work than GLP-1.
Not convinced. The evidence does not support that reading.
tendon and co-agonism literature in rodents is interesting
This is the "correlation is mechanism" thing again. You changed three variables at once.
long-acting amylin is co-agonism, different satiety profile
The research community is small on cagrilintide. Forum lore changes faster than data.
REDEFINE phase 24 readouts are interesting but 24 person REDEFINE is different from 24 trial REDEFINE.
That is net peptide content, not purity. Different number, different meaning.
Strongly agree. REDEFINE is phase 5, not final.
amylin receptor distribution is different from GLP-1
The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does REDEFINE.
This is correct. The co-agonism is real.
Mechanistically the bit that matters is cagrilintide. It explains most of the early profile and a decent chunk of the outcome.
the mechanism is different, the side effect profile reflects it
- 1Rodent or human data?9 comments in this branch · started by u/kavya_kravchenko
- 2Not convinced. The evidence does not support that reading.5 comments in this branch · started by u/sulphur_burps_sue