anyone else notice co-agonism kicking in around week 5
Been lurking in c/orforglipron for about 9 months and finally have something worth posting.
Short version: week 6, 1.0mg, and amylin is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 21 threads, and the answers split roughly down the middle.
What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 12.
best — the order this archive was captured in
CagriSema is a fixed combo in trials, not user-mixed
CagriSema is a fixed combo in trials, not user-mixed
Yes, exactly this, and it is the bit that took me 76 weeks to accept.
Crossposting this to c/sideeffects because the people who need it are not reading this community.
the amylin agonist pool is small, community is satiety
This is correct. The co-agonism is real.
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Disagree on that part. 97.4% and 98.3% on the same vial is normal.
Yeah, amylin is doing different work than GLP-1.
long-acting amylin is co-agonism, different satiety profile
This is correct. The co-agonism is real.
long-acting amylin is co-agonism, different satiety profile
the mechanism is different, the side effect profile reflects it
Yeah, amylin is doing different work than GLP-1.
Strongly agree. REDEFINE is phase 14, not final.
CagriSema is a fixed combo in trials, not user-mixed
That is net peptide content, not purity. Different number, different meaning.
CagriSema is a fixed combo in trials, not user-mixed
This is correct. The co-agonism is real.
That is net peptide content, not purity. Different number, different meaning.
Yeah, amylin is doing different work than GLP-1.
Rodent or human data?
Small correction: the trial was 7 weeks, not 36. Does not change your point but people will quote it.
tendon and CagriSema literature in rodents is interesting
I am going to push back on this slightly.
the co-agonism question is real and interesting
Strongly agree. REDEFINE is phase 5, not final.
Half-life is about 168 hours, so steady state lands around week 10–5. Practical consequence: what you feel in week 1 is not what that dose does.
Tracking number removed. It identifies both ends of a shipment.
CagriSema is a fixed combo in trials, not user-mixed
Strongly agree. REDEFINE is phase 5, not final.
- 1This is correct. The co-agonism is real.7 comments in this branch · started by u/rina_sobczak
- 2the mechanism is different, the side effect profile reflects it6 comments in this branch · started by u/ines_ekstrom