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c/cagrilintide·submitted 7 months ago by u/nz_unfunded

anyone else notice co-agonism kicking in around week 5

Labbranch of 6 comments

Been lurking in c/orforglipron for about 9 months and finally have something worth posting. Short version: week 6, 1.0mg, and amylin is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 21 threads, and the answers split roughly down the middle. What I actually want to know is…

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6 comments, started 7 months ago
u/ines_ekstrom115 points·7 months ago·edited

the mechanism is different, the side effect profile reflects it

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u/elin_lundgren-11 points·7 months ago

Yeah, amylin is doing different work than GLP-1.

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u/throwaway_44b154 points·7 months ago

Strongly agree. REDEFINE is phase 14, not final.

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u/zeynep_zielinski20 points·7 months ago

CagriSema is a fixed combo in trials, not user-mixed

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u/ms_fragmenter5 points·7 months ago

That is net peptide content, not purity. Different number, different meaning.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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