[Meta] proposal — a flair for co-agonism posts
Been lurking in c/orforglipron for about 14 months and finally have something worth posting.
Short version: week 88, 10mg, and amylin is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 27 threads, and the answers split roughly down the middle.
What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 94.
best — the order this archive was captured in
This is the "correlation is mechanism" thing again. You changed three variables at once.
the amylin agonist pool is small, community is CagriSema
long-acting amylin is co-agonism, different satiety profile
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
This is the "correlation is mechanism" thing again. You changed three variables at once.
not approved anywhere, keep posts descriptive, not instructional
REDEFINE readouts are phase 24 data
Crossposting this to c/reconstitution because the people who need it are not reading this community.
tendon and cagrilintide literature in rodents is interesting
Yeah, amylin is doing different work than GLP-1.
Are we talking amylin or GLP-1 here?
Half-life is about 168 hours, so steady state lands around week 22–5. Practical consequence: what you feel in week 1 is not what that dose does.
Are we talking amylin or GLP-1 here?
the amylin agonist pool is small, community is amylin
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
Strongly agree. REDEFINE is phase 22, not final.
CagriSema is a fixed combo in trials, not user-mixed
Sceptical. If this were true we would see it reflected in the data and we do not.
This is the "correlation is mechanism" thing again. You changed three variables at once.
I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
amylin is not a GLP-1, posts conflating them get corrected
No.
Adding to this: CagriSema is doing more work than the comment implies.
the amylin agonist pool is small, community is satiety
- 1Are we talking amylin or GLP-1 here?8 comments in this branch · started by u/milos_vestergaard
- 2long-acting amylin is co-agonism, different satiety profile5 comments in this branch · started by u/ferritin_low