u/joaquin_stanescu

the weight-loss conversation drowns out glycaemic control sometimes

the community lane table lives here

phase 2 is not phase 3, smaller n and shorter trial

Which trial and what was the primary endpoint?

okay but what dose of sema are you on

Did you time the injection consistently each week or was it more ad hoc?

Actual days or estimated?

Half-life is about 168 hours, so steady state lands around week 23–5. Practical consequence: what you feel in week 1 is not what that dose does.

Yeah, glycaemic control is the original use.

week 12 and i am still not at maintenance, do not rush the ladder

Mechanistically the bit that matters is titration. It explains most of the early profile and a decent chunk of the outcome.

type 2 is the indication, weight loss is the side effect

my eGFR moved before the scale did and i nearly missed it

the community lane table lives here

stalled at 0.25mg, went up, and regretted it, the stall would have broken anyway

the 9 week readout is different from the 21 week readout

This matches my experience almost exactly on the Ozempic pens. The titration is the whole point.

Sceptical. If this were true we would see it reflected in the data and we do not.

Strongly agree. Customs adds unpredictable delay.

This is what I tell everyone in c/newbiequestions and they never believe me until week 43.