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c/trialwatch·posted 1 year ago by u/adaeze_weiss

[Results] 27 weeks, 41kg, and endpoint was the hard part

Readout Clean Column ×9

Trying to settle this properly because the thread from last year went in circles.

The claim: FLOW matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 13 months without either producing anything.

What would actually settle it is 39 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

1,004 up / 361 down74% upvoted18 commentsid 10lrsh9 Aug 2024

18 comments

12 in this archive, depth 5

best — the order this archive was captured in

u/hsa_math47 points·1 year ago

event rates are more informative than hazard ratios alone

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u/tb500_tangent40 points·1 year ago
no
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u/trialwatch_theoMOD31 points·1 year ago

Tracking number removed. It identifies both ends of a shipment.

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u/bastian_ekstrom26 points·1 year ago

absolute risk reduction, not relative risk reduction, that is how you decide

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u/iman_castellanos35 points·1 year ago·edited

What was the dropout rate?

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u/rohan_steiner21 points·1 year ago

event rates are more informative than hazard ratios alone

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u/adaeze_weissOP-23 points·1 year ago

What was the dropout rate?

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u/joaquin_stanescu0 points·1 year ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/nordic_pricing27 points·1 year ago·edited

number-needed-to-treat is the house dialect

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u/alcohol_aversion20 points·1 year ago

Strongly agree. Phase 2 is investigational, not conclusive.

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u/enzo_ferrari11 points·1 year ago

This is correct. Discontinuation arms show the regain reality.

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u/karl_fischer_kev15 points·1 year ago

STEP 1 readout: 97.6% mean weight loss, absolute numbers matter. Spread around that mean is enormous.

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About c/trialwatch

Clinical trial reading group. New readouts, protocol amendments, endpoint definitions, dropout handling, and the difference between a press release and a publication. Absolute risk reduction and number-needed-to-treat are house dialect here.

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