u/janek_ferrari

Sceptical. If this were true we would see it reflected in the data and we do not.

Do you have baseline to compare to?

the 5mg arm is different from 5mg, results do not transfer

Yeah, 96.8% area is not the problem, the missing impurity breakdown is the problem.

sarcopenia is the unsolved question

Disagree. What you are describing is consistent with retatrutide, not with what you concluded.

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

This is correct. Triple agonism is genuinely different.

cite the discontinuation data rather than guessing regain rates

HOMA-IR is crude but free and useful for tracking

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

nobody should be giving this to anyone without extensive monitoring

Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.

Inter-lab variance on this kind of assay is routinely 1–2 points.

Yes, exactly this, and it is the bit that took me 69 weeks to accept.

STEP 1 and SURMOUNT-4 discontinuation arms show regain

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

never post a calculation as advice without stating the concentration

What were the related substances listed individually?

post reference ranges with your numbers, units differ by country and lab

axis labels included, always