three years of triple agonist threads, summarised so you do not have to read them
Confession thread, sort of.
I went from 7.5mg to 2.4mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 11 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.
So now I have early fullness I did not need and a data point I cannot interpret. Two lessons in one.
Posting it in the hope that somebody at week 12 reads it before doing the same thing.
best — the order this archive was captured in
Not convinced. The evidence does not support that reading.
TRIUMPH phase 2 showed 98.3% weight loss but the fatigue profile on the highest arm was rough. Phase 2 != phase 3.
TRIUMPH phase 2 showed 98.3% weight loss but the fatigue profile on the highest arm was rough.
Adding to this: TRIUMPH is doing more work than the comment implies.
phase 2 numbers are not maintenance numbers, cite the trial
[deleted]
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
the 2.5mg arm is different from 5mg, results do not transfer
Which trial arm and what was the n?
the glucagon component changes the side effect profile, not just the efficacy
Strongly agree. Heart rate escalation needs the actual data, not impressions.
triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual
phase 2 numbers are not maintenance numbers, cite the trial
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
The confident tone is doing a lot of work that the evidence is not.
nobody should be giving this to anyone without extensive monitoring
Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.
- 1TRIUMPH phase 2 showed 98.3% weight loss but the fatigue profile on the…10 comments in this branch · started by u/soren_nkemelu
- 2this should be in the wiki5 comments in this branch · started by u/cagrilintide_enthusiast