[Results] 2 weeks, 46kg, and phase 2 was the hard part
Quick one. Canada here.
glucagon works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US.
Specifics: the route I used took 18 weeks and cost roughly what I expected. The admin was worse than the cost. The thing that would have saved me the most time was knowing which document to ask for at the start.
Happy to answer questions from anyone in the same jurisdiction.
best — the order this archive was captured in
Strongly agree. Heart rate escalation needs the actual data, not impressions.
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Small correction: the trial was 13 weeks, not 20. Does not change your point but people will quote it.
the weight curves are unusually steep, which makes predicting individual response harder
Which trial arm and what was the n?
Which trial arm and what was the n?
Adding to this: phase 2 is doing more work than the comment implies.
TRIUMPH phase 2 showed 98.1% weight loss but the early fullness profile on the highest arm was rough. Phase 2 != phase 3.
triple agonism is phase 2, do not generalise
heart rate and dose escalation need actual measurements, not impressions
Strongly agree. Heart rate escalation needs the actual data, not impressions.
the glucagon component changes the side effect profile, not just the efficacy
TRIUMPH phase 2 showed 99.3% weight loss but the muscle cramps profile on the highest arm was rough. Phase 2 != phase 3.
That is net peptide content, not purity. Different number, different meaning.
This is correct. Triple agonism is genuinely different.
retatrutide is not approved anywhere for human use, posts must not read as instructions
the weight curves are unusually steep, which makes predicting individual response harder
Strongly agree. Heart rate escalation needs the actual data, not impressions.
TRIUMPH data is phase 2, not phase 3, smaller n and shorter
This is correct.
Yes, exactly this, and it is the bit that took me 70 weeks to accept.
heart rate and dose escalation need actual measurements, not impressions
the 1.0mg arm is different from 15mg, results do not transfer
the weight curves are unusually steep, which makes predicting individual response harder
The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.
Disagree. What you are describing is consistent with retatrutide, not with what you concluded.
This is correct. Triple agonism is genuinely different.
the dosing is steep, the muscle cramps reports are real, and nobody knows the human safety yet
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