c/retatrutide · created 6 Sep 2023
Triple agonist. Phase 3 data, research-grade material, and a lot of unknowns.
Jastreboff et al., N Engl J Med , 2023. Phase 2. Forty-eight weeks. Mean change −24.2% in the highest dose arm. Every one of those qualifiers gets dropped when the…
Right, the triple agonist question again, but with numbers this time. I have 24 data points over 24 weeks. The pattern is consistent enough that I do not think it is…
Trying to settle this properly because the thread from last year went in circles. The claim: glucagon matters. The counter-claim: it is measurement error. Both sides…
Week 23 update. 4kg down from the start, muscle cramps basically gone since about week 63. Things that worked: consistency, protein at breakfast, walking more than I…
Vendor-level purity averages over time, built from independent results rather than vendor claims. Transparent methodology, open dataset.
Browse resultsGenuinely asking, not being difficult. Everyone in c/newbiequestions repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and…
Right, the triple agonist question again, but with numbers this time. I have 17 data points over 12 weeks. The pattern is consistent enough that I do not think it is…
Trying to settle this properly because the thread from last year went in circles. The claim: glucagon matters. The counter-claim: it is measurement error. Both sides…
Quick one. Canada here. glucagon works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
I have had 11 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied…
Confession thread, sort of. I went from 10mg to 2.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 18 weeks…
Been lurking in c/progresspics for about 7 months and finally have something worth posting. Short version: week 28, 15mg, and TRIUMPH is the bit I still cannot get a…
phase 2. That is the whole post, but I will justify it. Everything else people worry about in c/glp1women is downstream of it. Titration speed, early fullness, the…
Something I noticed reading old threads that I have not seen said out loud. The advice on TRIUMPH in this community changed substantially around the start of last year,…
Genuinely asking, not being difficult. Everyone in c/glp1uk repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and when I…
Been lurking in c/sideeffects for about 18 months and finally have something worth posting. Short version: week 46, 12.5mg, and triple agonist is the bit I still cannot…
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standardsphase 2. That is the whole post, but I will justify it. Everything else people worry about in c/glp1canada is downstream of it. Titration speed, reflux, the endless…
Right, the triple agonist question again, but with numbers this time. I have 24 data points over 22 weeks. The pattern is consistent enough that I do not think it is…
Genuinely asking, not being difficult. Everyone in c/newbiequestions repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and…
Week 53 update. 34kg down from the start, reflux basically gone since about week 93. Things that worked: consistency, protein at breakfast, walking more than I want to.…
Trying to settle this properly because the thread from last year went in circles. The claim: glucagon matters. The counter-claim: it is measurement error. Both sides…
Trying to settle this properly because the thread from last year went in circles. The claim: glucagon matters. The counter-claim: it is measurement error. Both sides…
Week 12 update. 13kg down from the start, muscle cramps basically gone since about week 52. Things that worked: consistency, protein at breakfast, walking more than I…
Genuinely asking, not being difficult. Everyone in c/glp1uk repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and when I…
Right, the triple agonist question again, but with numbers this time. I have 10 data points over 30 weeks. The pattern is consistent enough that I do not think it is…
Long-ish post, sorry. tl;dr at the bottom. I have been tracking retatrutide against eGFR for 9 weeks because I could not find anyone who had. The correlation is weaker…
Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.
Certified reference materials for peptide identity and purity work.
sigmaaldrich.comSeveral compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.
Reference