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c/coa·posted 1 year ago by u/yusuf_nakamura

what would you tell week-1 you about area percent

COA Clean Column ×8 Sourced ×1 Long Haul ×3

Confession thread, sort of.

I went from 15mg to 7.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 7 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have muscle cramps I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 40 reads it before doing the same thing.

4,341 up / 425 down91% upvoted38 commentsid zowhht5 Mar 2025

38 comments

30 in this archive, depth 4

best — the order this archive was captured in

u/tomas_lehtinen423 points·1 year ago

the related substances line is where the story is

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u/clara_restrepo111 points·1 year ago·edited

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/chidi_demir379 points·1 year ago

Are you looking at area% or net peptide content? Different numbers.

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[removed]143 points·1 year ago

[removed by moderator]

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u/rania_okonkwo51 points·1 year ago

the related substances line is where the story is

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u/first_hundred115 points·1 year ago

[removed by moderator]

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/anders_kuusela235 points·1 year ago

axis labels included, always

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u/laila_yilmaz83 points·1 year ago

Cosigning. The batch number is load-bearing information.

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u/neha_erdogan312 points·1 year ago

Are you looking at area% or net peptide content? Different numbers.

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u/first_hundredMOD282 points·1 year ago

Retitled to remove editorialising. Put the evidence in the body.

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u/freya_baptista74 points·1 year ago

chromatogram or it did not happen

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u/gastric_emptying_g49 points·1 year ago

PDF metadata is checkable in fifteen seconds

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u/janek_ferrari40 points·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/ghrp_history162 points·1 year ago

Yeah, 96.8% area is not the problem, the missing impurity breakdown is the problem.

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u/amylin_amyamylin52 points·1 year ago

Did they give you the chromatogram or just the summary line?

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u/ahmed_rasmussen-9 points·1 year ago

This is the correct framing. The COA structure matters as much as the number.

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u/yannick_haddad170 points·1 year ago

PDF metadata is checkable in fifteen seconds

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u/milos_trevino60 points·1 year ago

Asked FGP for the batch-specific COA and they sent it within six hours, full document, batch number, date, everything. That is the baseline.

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u/milos_trevino98 points·1 year ago

Crossposting this to c/semaglutide because the people who need it are not reading this community.

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u/yusuf_nakamuraOP72 points·1 year ago

Sent one vial to Janoshik and VendorInvestigate. 99.2% and 99.1%. Cost me more than the vial did and I would do it again.

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u/yusuf_nakamura24 points·1 year ago·edited

Small correction: the trial was 23 weeks, not 17. Does not change your point but people will quote it.

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u/coa_janitormod · c/coa0 points·1 year ago

area% is not mass%, and here is exactly why it matters

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u/amira_dumitru69 points·1 year ago

axis labels included, always

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u/yusuf_nakamuraOP28 points·1 year ago

The confident tone is doing a lot of work that the evidence is not.

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u/zeynep_zielinski46 points·1 year ago

Are you looking at area% or net peptide content? Different numbers.

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u/zeynep_zielinski38 points·1 year ago·edited

redact your own name, not the vendor's batch details

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u/purity_pedantanalytical11 points·1 year ago

the batch number or it did not happen

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u/mikkel_correia2 points·1 year ago

Strongly agree. Mass% and area% are answering different questions on the same document.

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About c/coa

How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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