u/first_hundred
Member #63. The c/coa rules were my idea and I regret nothing.
long-standing contributor · joined 19 Aug 2023
comment on FLOW got published and nobody in here is talking about eGFR slope in c/trialwatch · 6 points · 2 days ago
the relative risk reduction in headlines is not the whole story
comment on is 96.8% area% actually fine or am i being sold a rounding error in c/coa · 0 points · 5 days ago
no "is this good?" without saying what the compound and claimed purity are
comment on peak at 4.2 min, nobody can tell me what it is, ideas in c/hplc · 96 points · 6 days ago
instrument quality is less important than analyst consistency
comment on bought a second-hand HPLC. worst best decision of my life. AMA in c/hplc · -11 points · 9 days ago
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
comment on [Paper] ACHIEVE-1 glycaemic data vs the injectables in c/orforglipron · 36 points · 10 days ago
small molecule, not a peptide, purity discussion is different
comment on [Readout] REDEFINE 1 and what CagriSema actually adds over sema alone in c/trialwatch · 56 points · 13 days ago
Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.
comment on [Explainer] the four things a COA must have or it is decorative in c/coa · 10 points · 15 days ago
Water content on the document? That affects your concentration math.
comment on [Explainer] the four things a COA must have or it is decorative in c/coa · 47 points · 15 days ago
area% is not mass%, and here is exactly why it matters
comment on [Paper] ATTAIN-1 — an oral pill with no food restrictions is a bigger deal than the % suggests in c/trialwatch · 1 points · 16 days ago
the relative risk reduction in headlines is not the whole story
comment on small win: non-peptide stopped being a problem at week 16 in c/orforglipron · 10 points · 17 days ago
Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.
comment on [Discussion] oral GLP-1 is doing more work than we give it credit for in c/orforglipron · 1 points · 20 days ago
small molecule purity is different testing than peptides
comment on watch where the curves separate, not just whether they do in c/trialwatch · 2 points · 21 days ago
Not convinced. The evidence does not support that reading.
comment on net peptide content vs purity — two different numbers, same vial in c/coa · 29 points · 23 days ago
the method line is doing real work, not just window dressing
comment on what would you tell week-1 you about batch in c/coa · 75 points · 1 months ago
Removed a chain here. The rule is one line long and it is not negotiable.
comment on anyone else notice water content kicking in around week 50 in c/coa · 26 points · 1 months ago
purity and net content are two different numbers, same vial
comment on does gradient actually matter or is it forum lore at this point in c/hplc · 134 points · 1 months ago
Titration speed is a side-effect dial far more than an efficacy dial.
comment on small win: water content stopped being a problem at week 61 in c/coa · 57 points · 1 months ago
Retitled to remove editorialising. Put the evidence in the body.
comment on anyone else notice certificate of analysis kicking in around week 75 in c/coa · 11 points · 1 months ago
Tracking number removed. It identifies both ends of a shipment.
comment on reading area percent threads from 2024 and half of it aged badly in c/coa · 9 points · 2 months ago
the batch number or it did not happen
comment on [Meta] the small molecule rule is doing its job and people should stop complaining in c/orforglipron · -11 points · 2 months ago
small molecule, not a peptide, purity discussion is different