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c/coa·posted 1 year ago by u/step_therapy_s

[Discussion] we are measuring certificate of analysis at the wrong time and calling it noise

Discussion Long Haul ×1

Posting this because I searched for it and got nothing useful.

Setup: 12.5mg, week 79, sulphur burps present but not ruining anything. I changed exactly one variable — related substances — and tracked it for 12 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

648 up / 202 down76% upvoted18 commentsid qfx723 Dec 2024

18 comments

18 in this archive, depth 4

best — the order this archive was captured in

u/dario_boateng62 points·1 year ago

the batch number or it did not happen

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u/tove_ogunleye19 points·1 year ago·edited

the batch number or it did not happen

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/coa_janitorMOD38 points·1 year ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/tidy_vialdrawer_watch28-3 points·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/tidy_vialdrawer_watch281 point·1 year ago

axis labels included, always

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u/nadia_fonseca43 points·1 year ago

Asked HJ for the batch-specific COA and they sent it within six hours, full document, batch number, date, everything. That is the baseline.

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u/valeria_girard11 points·1 year ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/alcohol_aversion7 points·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/aleksi_eriksen27 points·1 year ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/janek_ferrari19 points·1 year ago

axis labels included, always

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u/kavya_verhoeven19 points·1 year ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/step_therapy_sOP11 points·1 year ago

post the whole document, not the headline number

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u/karma_irrelevant12 points·1 year ago

Crossposting this to c/semaglutide because the people who need it are not reading this community.

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u/reflux_report3 points·1 year ago

area% is not mass%, and here is exactly why it matters

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u/certified_referenceQC15 points·1 year ago

the batch number or it did not happen

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u/freya_baptista7 points·1 year ago

redact your own name, not the vendor's batch details

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u/ismael_eriksen5 points·1 year ago

Crossposting this to c/semaglutide because the people who need it are not reading this community.

Disagree on that part. 98.1% and 98.4% on the same vial is normal.

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About c/coa

How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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Independent HPLC and mass spec. The number you get is the number they found.

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c/coa rules
  1. Post the full document. Cropped COAs that hide the batch number or date get removed.
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