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c/tapering·posted 1 year ago by u/piotr_bruun

tapering vs regain — genuinely asking which matters more

Question Clean Column ×7

Posting this because I searched for it and got nothing useful.

Setup: 0.25mg, week 82, injection-site soreness present but not ruining anything. I changed exactly one variable — regain — and tracked it for 6 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

924 up / 275 down77% upvoted25 commentsid g73wwi18 Feb 2025

25 comments

23 in this archive, depth 5

best — the order this archive was captured in

u/controversial_only88 points·1 year ago

Strongly agree. The regain is expected.

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u/arne_amankwah23 points·1 year ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/janek_ferrari19 points·1 year ago

cite the discontinuation data rather than guessing regain rates

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u/coldchain_karencold chain12 points·1 year ago

the regain is treatment of chronic condition ending, not failure

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u/coa_janitormod · c/coa76 points·1 year ago

Second this question. I have wondered about interval stretching for 4 months and never seen a straight answer.

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u/hana_lehtinen34 points·1 year ago

This is correct. Discontinuation data is real.

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u/valeria_cardoso25 points·1 year ago

Small correction: the trial was 18 weeks, not 31. Does not change your point but people will quote it.

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u/piotr_bruunOP-14 points·1 year ago

Sweden here. Waited 22 months on a list, gave up, went private, and the total cost was roughly what I expected.

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u/arne_amankwah1 point·1 year ago

the regain is treatment of chronic condition ending, not failure

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u/teodor_lokken1 point·1 year ago

cite the discontinuation data rather than guessing regain rates

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u/marta_weiss51 points·1 year ago

Half-life is about 168 hours, so steady state lands around week 20–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/cormac_roos42 points·1 year ago

Which country? Half the answers in this thread only apply in the Netherlands.

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u/piotr_bruunOP0 points·1 year ago

coming off deliberately, not by accident

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u/britta_boateng1 point·1 year ago·edited

STEP 1 and SURMOUNT-4 discontinuation arms show regain

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u/rina_bergstrom34 points·1 year ago

This is correct. Discontinuation data is real.

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u/piotr_bruunOP22 points·1 year ago

regain on taper is expected, plan for it

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u/dario_stanescu13 points·1 year ago

appetite return timelines vary interval stretching

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u/viktor_kirchner38 points·1 year ago

Strongly agree. The regain is expected.

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u/micro_bump_mick21 points·1 year ago

the people who came off and restarted without shame

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u/ignacio_silva18 points·1 year ago

Week 61 for me and the honest summary is: 39kg down, sulphur burps manageable, and I have thought about food maybe four times today.

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u/helga_vermeulen6 points·1 year ago·edited

Has anyone actually got this in writing, or is it forum lore at this point?

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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