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c/tapering·posted 1 year ago by u/ismael_eriksen

tried interval stretching for 3 weeks. here is what happened.

Results Clean Column ×5 Cold Box ×1 Well Actually ×1

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking appetite return against eGFR for 23 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

3,222 up / 547 down85% upvoted29 commentsid fd89bk10 Mar 2025

29 comments

26 in this archive, depth 4

best — the order this archive was captured in

u/skip_week_scepticMOD276 points·1 year ago

Retitled to remove editorialising. Put the evidence in the body.

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u/maren_baptista126 points·1 year ago

interval stretching versus dose reduction

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u/viktor_laurent206 points·1 year ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/ilias_nakamura136 points·1 year ago

Inter-lab variance on this kind of assay is routinely 1–2 points.

Disagree on that part. 93.7% and 99.3% on the same vial is normal.

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u/marisol_kravchenko42 points·1 year ago

What are you comparing it against though?

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u/neha_krastev127 points·1 year ago

regain on taper is expected, plan for it

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u/ismael_eriksenOP-13 points·1 year ago

Which country? Half the answers in this thread only apply in Canada.

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u/hana_lehtinen116 points·1 year ago

The injection-site soreness was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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u/priya_weiss47 points·1 year ago

the people who came off and restarted without shame

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u/valeria_girard74 points·1 year ago

How many weeks between the two measurements?

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u/viktor_kirchner55 points·1 year ago

Yeah, regain is not a failure.

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[removed]37 points·1 year ago

[removed by moderator]

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u/diego_szabo79 points·1 year ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/ismael_eriksenOP32 points·1 year ago

interval stretching versus dose reduction

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u/dizzy_on_standing49 points·1 year ago

Mechanistically the bit that matters is discontinuation. It explains most of the early profile and a decent chunk of the outcome.

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u/nikhil_lindqvist14 points·1 year ago·edited

tapering instructions are not welcome here

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u/aleksi_lehtinen15 points·1 year ago·edited

Poland here. Waited 18 months on a list, gave up, went private, and the total cost was roughly what I expected.

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u/chain_confirm_cpayments8 points·1 year ago

regain on taper is expected, plan for it

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u/maren_baptista35 points·1 year ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/ismael_eriksen10 points·1 year ago

Small correction: the trial was 12 weeks, not 8. Does not change your point but people will quote it.

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u/piotr_bruun12 points·1 year ago

the people who came off and restarted without shame

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u/appeal_letter_al3 points·1 year ago

Not convinced. The evidence does not support that reading.

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u/anders_kuusela19 points·1 year ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/yara_lindholm11 points·1 year ago

tapering instructions are not welcome here

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u/taper_off_tabitha3 points·1 year ago

tapering instructions are not welcome here

Disagree on that part. 97.4% and 96.8% on the same vial is normal.

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u/lift_heavy_thingsresistance training9 points·1 year ago

Yeah, regain is not a failure.

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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